ZFIN is now using GRCz12tu for Genomic Data
Gene
slit2
- ID
- ZDB-GENE-010306-3
- Name
- slit homolog 2 (Drosophila)
- Symbol
- slit2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable Roundabout binding activity and heparin binding activity. Acts upstream of or within several processes, including endocardial progenitor cell migration to the midline involved in heart field formation; negative regulation of axon extension; and nervous system development. Predicted to be located in extracellular space. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and oocyte. Orthologous to human SLIT2 (slit guidance ligand 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000372 | Leucine-rich repeat N-terminal domain |
| Domain | IPR000483 | Cysteine-rich flanking region, C-terminal |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001791 | Laminin G domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR003645 | Follistatin-like, N-terminal |
| Domain | IPR006207 | Cystine knot, C-terminal |
| Family | IPR051355 | Notch and Slit guidance protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers