Gene

six5

ID

ZDB-GENE-010201-3

Name

SIX homeobox 5

Symbol

six5 Nomenclature History

Previous Names

six4.3

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX5 (SIX homeobox 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu588 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With six5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
branchiootorenal syndrome 2	Alliance	Branchiootorenal syndrome 2	610896

Associated With six5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR031701	Homeobox protein SIX1, N-terminal SD domain
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily