Gene
ntrk3b
- ID
- ZDB-GENE-010126-4
- Name
- neurotrophic tyrosine kinase, receptor, type 3b
- Symbol
- ntrk3b Nomenclature History
- Previous Names
-
- trkC2 (1)
- si:dkey-18e5.1
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of neuron projection development; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in axon and plasma membrane. Is expressed in nervous system and otic vesicle. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma; colorectal cancer; and stomach cancer. Orthologous to human NTRK3 (neurotrophic receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016011Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029280Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa20876 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30359 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30360 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa30361 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40849 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR002011 | Tyrosine-protein kinase, receptor class II, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Growth factor receptor NTRK | Growth factor receptor NTRK, leucine rich repeat C-terminal | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class II, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0H2UKW5 | InterPro | 813 | |||||||||||||||||||
| UniProtKB:A0A8M1RHB8 | InterPro | 818 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ntrk3b-201
(1)
|
Ensembl | 4,313 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-185L10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-69I13 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-276G11 | ZFIN Curated Data | |
| Contains | STS | zfishg-a1757f01.p1c | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002662753 (1) | 4005 nt | ||
| Genomic | GenBank:BX571970 (2) | 170614 nt | ||
| Polypeptide | UniProtKB:A0A8M1RHB8 (1) | 818 aa |
- Hahn, K., Manuel, P., Bouldin, C. (2020) Expression of the neurotrophic tyrosine kinase receptors, ntrk1 and ntrk2a, precedes expression of other ntrk genes in embryonic zebrafish. PeerJ. 8:e10479
- Nittoli, V., Sepe, R.M., Coppola, U., D'Agostino, Y., De Felice, E., Palladino, A., Vassalli, Q.A., Locascio, A., Ristoratore, F., Spagnuolo, A., D'Aniello, S., Sordino, P. (2018) A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish. The Journal of comparative neurology. 526(6):1057-1072
- Hui, S.P., Sheng, D.Z., Sugimoto, K., Gonzalez-Rajal, A., Nakagawa, S., Hesselson, D., Kikuchi, K. (2017) Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs. Developmental Cell. 43:659-672.e5
- Auer, T.O., Xiao, T., Bercier, V., Gebhardt, C., Duroure, K., Concordet, J.P., Wyart, C., Suster, M., Kawakami, K., Wittbrodt, J., Baier, H., Del Bene, F. (2015) Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3. eLIFE. 4
- Panza, P., Sitko, A.A., Maischein, H.M., Koch, I., Flötenmeyer, M., Wright, G.J., Mandai, K., Mason, C.A., Söllner, C. (2015) The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm. Neural Development. 10:23
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Pan, Y.A., Choy, M., Prober, D.A., and Schier, A.F. (2012) Robo2 determines subtype-specific axonal projections of trigeminal sensory neurons. Development (Cambridge, England). 139(3):591-600
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466
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