Gene
ntrk2a
- ID
- ZDB-GENE-010126-1
- Name
- neurotrophic tyrosine kinase, receptor, type 2a
- Symbol
- ntrk2a Nomenclature History
- Previous Names
-
- trkB1 (1)
- si:ch211-148p15.2
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have neurotrophin binding activity; neurotrophin receptor activity; and transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of neuron projection development; and regulation of intracellular signal transduction. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Is expressed in endoderm; mesoderm; nervous system; neural tube; and pharyngeal epithelium. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 15 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
developmental and epileptic encephalopathy 58 | Alliance | Developmental and epileptic encephalopathy 58 | 617830 |
Obesity, hyperphagia, and developmental delay | 613886 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Protein | Length |
---|---|
UniProtKB:A0A8M3B589
|
787 |
UniProtKB:A0A8M3AVL1
|
791 |
UniProtKB:A0A8M3B2B0
|
447 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
ntrk2a-202
(1)
|
3735 nt | |
ncRNA |
ntrk2a-002
(1)
|
550 nt |
Interactions and Pathways
No data available
Plasmids
No data available