Gene
daxx
- ID
- ZDB-GENE-010110-3
- Name
- death-domain associated protein
- Symbol
- daxx Nomenclature History
- Previous Names
-
- si:dz179b20.7
- wu:fd15c03
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription; nucleosome assembly; and regulation of apoptotic process. Predicted to act upstream of or within apoptotic process and chromatin organization. Located in nucleus. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in appendiceal neoplasm; islet cell tumor; oral squamous cell carcinoma; ovary epithelial cancer; and pancreatic endocrine carcinoma. Orthologous to human DAXX (death domain associated protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Qi et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Daxx, histone-binding domain | Daxx, histone-binding domain superfamily | Daxx, N-terminal domain superfamily | Daxx, N-terminal Rassf1C-interacting domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q1LUU4 | InterPro | 716 | ||||
| UniProtKB:A0A8M6YWD7 | InterPro | 762 | ||||
| UniProtKB:A0A8M2B6F2 | InterPro | 763 | ||||
| UniProtKB:A0AB32TB48 | InterPro | 715 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-213J4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-264N13 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-44O19 | ZFIN Curated Data | |
| Contained in | PAC | BUSM1-179B20 | ||
| Contains | SNP | rs3728958 | Stickney et al., 2002 | |
| Contains | SNP | rs3728959 | Stickney et al., 2002 | |
| Contains | SNP | rs3728960 | Stickney et al., 2002 | |
| Contains | SNP | rs3728961 | Stickney et al., 2002 | |
| Encodes | EST | fd15c03 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044949 (1) | 2722 nt | ||
| Genomic | GenBank:BX927188 (1) | 163213 nt | ||
| Polypeptide | UniProtKB:A0A8M2B6F2 (1) | 763 aa |
- Honjo, Y., Takano, K., Ichinohe, T. (2020) Characterization of novel zebrafish MHC class I U lineage genes and their haplotype. Developmental and comparative immunology. 116:103952
- McConnell, S.C., Hernandez, K.M., Wcisel, D.J., Kettleborough, R.N., Stemple, D.L., Yoder, J.A., Andrade, J., de Jong, J.L. (2016) Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution. Proceedings of the National Academy of Sciences of the United States of America. 113(34):E5014-23
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Qi, L., Xiang, Z. (2015) Molecular cloning and expression analysis of an apoptosis-associated gene Daxx from zebrafish, Danio rerio. Fish & shellfish immunology. 45(1):59-66
- Cox, S.G., Kim, H., Garnett, A.T., Medeiros, D.M., An, W., and Crump, J.G. (2012) An essential role of variant histone h3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genetics. 8(9):e1002938
- de Jong, J.L., Burns, C.E., Chen, A.T., Pugach, E., Mayhall, E.A., Smith, A.C., Feldman, H.A., Zhou, Y., and Zon, L.I. (2011) Characterization of immune-matched hematopoietic transplantation in zebrafish. Blood. 117(16):4234-42
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
- Tallafuss, A., Hale, L.A., Yan, Y.L., Dudley, L., Eisen, J.S., and Postlethwait, J.H. (2006) Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Gene expression patterns : GEP. 6(5):556-565
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Liu, R.Z., Denovan-Wright, E.M., and Wright, J.M. (2003) Structure, linkage mapping and expression of the heart-type fatty acid-binding protein gene (fabp3 ) from zebrafish (Danio rerio). European journal of biochemistry. 270(15):3223-3334
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