Gene

robo2

ID
ZDB-GENE-001019-1
Name
roundabout, axon guidance receptor, homolog 2 (Drosophila)
Symbol
robo2 Nomenclature History
Previous Names
  • ast
  • astray
  • sb:eu937
  • unp1881
  • zmp:0000000549 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Is predicted to enable axon guidance receptor activity. Acts upstream of or within several processes, including axon development; regulation of extent of cell growth; and sensory perception of touch. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With robo2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vesicoureteral reflux Alliance Vesicoureteral reflux 2 610878
Associated With robo2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013106 Immunoglobulin V-set domain
Family IPR032986 Roundabout homologue 1
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Immunoglobulin V-set domain Roundabout homologue 1
UniProtKB:Q1LY64 128
UniProtKB:A0A2R8Q4U8 136
UniProtKB:Q19S04 111
UniProtKB:A4JYH1 862
UniProtKB:Q804R9 20
UniProtKB:Q90Z70 1513
UniProtKB:Q19S05 46
UniProtKB:F1QBD4 1387
UniProtKB:B8K0D7 399
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations