Gene

fech

ID
ZDB-GENE-000928-1
Name
ferrochelatase
Symbol
fech Nomenclature History
Previous Names
  • fch (1)
  • dracula
  • drc
  • frx
  • zgc:109851
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Exhibits ferrochelatase activity. Involved in erythrocyte maturation. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Is expressed in blood; intermediate cell mass of mesoderm; posterior lateral plate mesoderm; and ventral mesoderm. Orthologous to human FECH (ferrochelatase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fech Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
erythropoietic protoporphyria Alliance Protoporphyria, erythropoietic, 1 177000
Associated With fech Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019772 Ferrochelatase, active site
Domain IPR033644 Ferrochelatase, C-terminal
Domain IPR033659 Ferrochelatase, N-terminal
Family IPR001015 Ferrochelatase
Domain Details Per Protein
Protein Length Ferrochelatase Ferrochelatase, active site Ferrochelatase, C-terminal Ferrochelatase, N-terminal
UniProtKB:Q568U9 409
UniProtKB:Q9DFU9 409
UniProtKB:F1R362 409
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations