Gene

adarb1a

ID
ZDB-GENE-000627-2
Name
adenosine deaminase RNA specific B1a
Symbol
adarb1a Nomenclature History
Previous Names
  • ADAR2 (1)
  • adarb1
  • RED1
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Is predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in RNA processing and adenosine to inosine editing. Acts upstream of or within several processes, including embryonic cranial skeleton morphogenesis; lateral line development; and neural crest cell development. Is expressed in several structures, including ceratobranchial cartilage; fin bud; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Li et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adarb1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with hypotonia, microcephaly, and seizures 618862
Associated With adarb1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002466 Adenosine deaminase/editase
Domain IPR014720 Double-stranded RNA-binding domain
Domain IPR044458 ADAR2, first double-stranded RNA binding domain
Domain IPR044459 ADAR2, second double-stranded RNA binding domain
Domain Details Per Protein
Protein Length ADAR2, first double-stranded RNA binding domain ADAR2, second double-stranded RNA binding domain Adenosine deaminase/editase Double-stranded RNA-binding domain
UniProtKB:A5WUX0 689
UniProtKB:Q1RM21 233
UniProtKB:Q9I8Y1 367
UniProtKB:A5WUX1 720
UniProtKB:Q90VY9 720
UniProtKB:Q90VZ1 689
UniProtKB:Q504H1 233
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations