Gene
krt4
- ID
- ZDB-GENE-000607-83
- Name
- keratin 4
- Symbol
- krt4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be located in intermediate filament. Predicted to be active in keratin filament. Is expressed in several structures, including digestive system; ectoderm; endocrine system; head; and integument.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 50 figures from 29 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb59 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ki127Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ki128Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ki129Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| sa38567 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45260 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-krt4 | (2) | |
| MO1-krt4 | N/A | Pei et al., 2007 |
| MO2-krt4 | N/A | Freisinger et al., 2014 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Intermediate filament, rod domain | Keratin, type II | Keratin type II head |
|---|---|---|---|---|---|
| UniProtKB:F1QK60 | InterPro | 497 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Et(krt4:EGFP) |
|
| 379 | (147) | |
| Et3(krt4:EGFP) |
|
| 2 | Shen et al., 2018 | |
| Et4(krt4:EGFP) |
|
| 4 | Shen et al., 2018 | |
| Et5(krt4:EGFP) |
|
| 1 | (2) | |
| Et6(krt4:EGFP) |
|
| 6 | Shen et al., 2021 | |
| Et(krt4:GAP-KillerRed) |
|
| 10 | (19) | |
| Et(krt4:ZmDissociation-EGFP) |
|
| 1 | (3) | |
| Tg2(krt4:EGFP) |
|
| 1 | (4) | |
| Tg2(krt4:EGFP-CAAX) |
|
| 1 | Kuroda et al., 2018 | |
| Tg2(krt4:GFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-195M11 | ZFIN Curated Data | |
| Encodes | EST | cb59 | Thisse et al., 2001 | |
| Encodes | EST | cegs956 | Rauch et al., 2003 | |
| Encodes | EST | fa91a11 | ||
| Encodes | EST | fd19e09 | ZFIN Curated Data | |
| Encodes | EST | fl23c09 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76893 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174788 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131509 (1) | 2498 nt | ||
| Genomic | GenBank:CR753817 (1) | 236737 nt | ||
| Polypeptide | UniProtKB:F1QK60 (1) | 497 aa |
No data available
- Horn, A., Wagner, A.S., Hou, Y., Zajac, J.C., Fister, A.M., Chen, Z., Pashaj, J., Junak, M., Mercado Soto, N.M., Gibson, A., Huttenlocher, A. (2025) Isotonic medium treatment limits burn wound microbial colonisation and improves tissue repair. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 33:e13242e13242
- Caetano da Silva, C., Macias Trevino, C., Mitchell, J., Murali, H., Tsimbal, C., Dalessandro, E., Carroll, S.H., Kochhar, S., Curtis, S.W., Cheng, C.H.E., Wang, F., Kutschera, E., Carstens, R.P., Xing, Y., Wang, K., Leslie, E.J., Liao, E.C. (2024) Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Communications biology. 7:10401040
- Liu, Z., Meng, Y., Ishikura, A., Kawakami, A. (2024) Live tracking of basal stem cells of the epidermis during growth, homeostasis and injury response in zebrafish. Development (Cambridge, England). 151(2):
- Cuevas, M., Terhune, E., Wethey, C., James, M., Netsanet, R., Grofova, D., Monley, A., Hadley Miller, N. (2023) Cytoskeletal Keratins Are Overexpressed in a Zebrafish Model of Idiopathic Scoliosis. Genes. 14(5):
- Mi, J., Andersson, O. (2023) Efficient knock-in method enabling lineage tracing in zebrafish. Life science alliance. 6(5)
- Mi, J., Liu, K.C., Andersson, O. (2023) Decoding pancreatic endocrine cell differentiation and β cell regeneration in zebrafish. Science advances. 9:eadf5142
- Seaver, A.W., Weaver, N.S., Iovine, M.K. (2023) Retinoic Acid Influences connexin43 Expression During Joint Formation in the Regenerating Zebrafish Fin. Bioelectricity. 5:173180173-180
- Tamás, S.X., Roux, B.T., Vámosi, B., Dehne, F.G., Török, A., Fazekas, L., Enyedi, B. (2023) A genetically encoded sensor for visualizing leukotriene B4 gradients in vivo. Nature communications. 14:46104610
- Vöcking, O., Famulski, J.K. (2023) A temporal single cell transcriptome atlas of zebrafish anterior segment development. Scientific Reports. 13:56565656
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
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