Gene

kat6b

ID
ZDB-GENE-000607-52
Name
K(lysine) acetyltransferase 6B
Symbol
kat6b Nomenclature History
Previous Names
  • id:ibd5103 (1)
  • si:dkey-24f15.3 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable chromatin binding activity; histone H3 acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleosome assembly and regulation of DNA-templated transcription. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in chromatin and nucleus. Is expressed in forebrain. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Kudoh et al., 2001
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa1676Allele with one point mutationUnknownPremature StopENU
sa14848Allele with one point mutationUnknownPremature StopENU
sa15696Allele with one point mutationUnknownPremature StopENU
sa16535Allele with one point mutationUnknownPremature StopENU
sa42204Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
MO1-kat6bN/A (2)
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Human Disease
Associated With kat6b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Ohdo syndrome, SBBYS variant Alliance SBBYSS syndrome 603736
Genitopatellar syndrome 606170
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Associated With kat6b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001965 Zinc finger, PHD-type
Domain IPR002717 Histone acetyltransferase domain, MYST-type
Domain IPR005818 Linker histone H1/H5, domain H15
Domain IPR019787 Zinc finger, PHD-finger
Domain IPR040706 MYST, zinc finger domain
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Domain Details Per Protein
Protein Additional Resources Length Acyl-CoA N-acyltransferase Histone acetyltransferase domain, MYST-type Linker histone H1/H5, domain H15 MYST family histone acetyltransferases MYST, zinc finger domain SAM domain-containing protein 1-like, WH domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily Zinc finger, FYVE/PHD-type Zinc finger, PHD-finger Zinc finger, PHD-type Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M3B851 InterPro 1856
UniProtKB:A0A8M3BER5 InterPro 2044
UniProtKB:A0A8M3B5C9 InterPro 1762
UniProtKB:A0A8M3AZ79 InterPro 2043
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 13
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA kat6b-201 (1) Ensembl 3,114 nt
mRNA kat6b-202 (1) Ensembl 4,107 nt
mRNA kat6b-203 (1) Ensembl 1,938 nt
mRNA kat6b-204 (1) Ensembl 453 nt
mRNA kat6b-205 (1) Ensembl 978 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-24F15ZFIN Curated Data
EncodesESTibd5103
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanKAT6B10
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
MouseKat6b14
Amino acid sequence comparison (1)
Conserved genome location (synteny) (1)
Citations
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