Gene
kat6b
- ID
- ZDB-GENE-000607-52
- Name
- K(lysine) acetyltransferase 6B
- Symbol
- kat6b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable chromatin binding activity; histone H3 acetyltransferase activity; and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within nucleosome assembly and regulation of DNA-templated transcription. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in chromatin and nucleus. Is expressed in forebrain. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa1676 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14848 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15696 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16535 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42204 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ohdo syndrome, SBBYS variant | Alliance | SBBYSS syndrome | 603736 |
| Genitopatellar syndrome | 606170 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA N-acyltransferase | Histone acetyltransferase domain, MYST-type | Linker histone H1/H5, domain H15 | MYST family histone acetyltransferases | MYST, zinc finger domain | SAM domain-containing protein 1-like, WH domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B851 | InterPro | 1856 | ||||||||||||
| UniProtKB:A0A8M3BER5 | InterPro | 2044 | ||||||||||||
| UniProtKB:A0A8M3B5C9 | InterPro | 1762 | ||||||||||||
| UniProtKB:A0A8M3AZ79 | InterPro | 2043 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-24F15 | ZFIN Curated Data | |
| Encodes | EST | ibd5103 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009307392 (1) | 8104 nt | ||
| Genomic | GenBank:AL929334 (1) | 226833 nt | ||
| Polypeptide | UniProtKB:A0A8M3BER5 (1) | 2044 aa |
- Zhou, W.H., Luo, Y., Li, R.X., Degrace, P., Jourdan, T., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2023) Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of raptor in zebrafish. The Journal of biological chemistry. 299(10):105220
- Ren, J., Long, Y., Liu, R., Song, G., Li, Q., Cui, Z. (2021) Characterization of Biological Pathways Regulating Acute Cold Resistance of Zebrafish. International Journal of Molecular Sciences. 22(6):
- Fellous, A., Earley, R.L., Silvestre, F. (2019) Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (Hdac) and lysine acetyltransferase (Kat) genes. Gene. 691:56-69
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Loh, S.L., Teh, C., Muller, J., Guccione, E., Hong, W., Korzh, V. (2014) Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line. Scientific Reports. 4:4289
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
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