ZFIN is now using GRCz12tu for Genomic Data
Gene
adgrl2a
- ID
- ZDB-GENE-000607-49
- Name
- adhesion G protein-coupled receptor L2a
- Symbol
- adgrl2a Nomenclature History
- Previous Names
-
- lphn2
- lphn2a
- id:ibd2808
- lphn2.1 (1)
- wu:fb72a08
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable G protein-coupled receptor activity. Acts upstream of or within endothelial cell-cell adhesion; negative regulation of hippo signaling; and regulation of vascular permeability. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; eye; and tail bud. Orthologous to human ADGRL2 (adhesion G protein-coupled receptor L2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Camillo et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2614 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9239 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa9378 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa13747 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21847 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21848 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21849 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41780 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41781 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41782 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000203 | GPS motif |
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR000922 | D-galactoside/L-rhamnose binding SUEL lectin domain |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR003112 | Olfactomedin-like domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | D-galactoside/L-rhamnose binding SUEL lectin domain | D-galactoside/L-rhamnose binding SUEL lectin domain superfamily | GAIN domain superfamily | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2, latrophilin | GPCR, family 2, latrophilin, C-terminal | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | GPS motif | Olfactomedin-like domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QDE0 | InterPro | 1273 | ||||||||||||
| UniProtKB:F1QPV2 | InterPro | 1472 | ||||||||||||
| UniProtKB:A0A8M9QDD0 | InterPro | 1515 | ||||||||||||
| UniProtKB:A0A8M9QDD5 | InterPro | 1429 | ||||||||||||
| UniProtKB:A0A8M9QHX3 | InterPro | 1272 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adgrl2a-201
(1)
|
Ensembl | 6,618 nt | ||
| mRNA |
adgrl2a-203
(1)
|
Ensembl | 6,643 nt | ||
| mRNA |
adgrl2a-204
(1)
|
Ensembl | 6,823 nt | ||
| mRNA |
adgrl2a-205
(1)
|
Ensembl | 6,651 nt | ||
| mRNA |
adgrl2a-206
(1)
|
Ensembl | 6,374 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-146A2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-174N22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-268B10 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-38E8 | ZFIN Curated Data | |
| Encodes | EST | fb72a08 | ||
| Encodes | EST | ibd2808 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_073916304 (1) | GRCz12tu | 5693 nt | |
| Genomic | GenBank:CR628406 (2) | 145678 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q7G8 (1) | 1520 aa |
- Comparative Orthology
- Alliance
- Yilmaz, O., Com, E., Pineau, C., Bobe, J. (2023) Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio). Scientific Reports. 13:1879518795
- Camillo, C., Facchinello, N., Villari, G., Mana, G., Gioelli, N., Sandri, C., Astone, M., Tortarolo, D., Clapero, F., Gays, D., Oberkersch, R.E., Arese, M., Tamagnone, L., Valdembri, D., Santoro, M.M., Serini, G. (2021) LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion. The Journal of cell biology. 220(11):
- Yilmaz, O., Patinote, A., Nguyen, T., Com, E., Pineau, C., Bobe, J. (2019) Genome editing reveals reproductive and developmental dependencies on specific types of vitellogenin in zebrafish (Danio rerio). Molecular reproduction and development. 86(9):1168-1188
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Schüttler, A., Reiche, K., Altenburger, R., Busch, W. (2017) The transcriptome of the zebrafish embryo after chemical exposure - a meta-analysis. Toxicological sciences : an official journal of the Society of Toxicology. 157(2):291-304
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62
- See, K., Yadav, P., Giegerich, M., Cheong, P.S., Graf, M., Vyas, H., Lee, S.G., Mathavan, S., Fischer, U., Sendtner, M., and Winkler, C. (2014) SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Human molecular genetics. 23(7):1754-70
- Groh, K.J., Schoenenberger, R., Eggen, R.I., Segner, H., and Suter, M.J. (2013) Analysis of protein expression in zebrafish during gonad differentiation by targeted proteomics. General and comparative endocrinology. 193:210-20
- Lange, M., Norton, W., Coolen, M., Chaminade, M., Merker, S., Proft, F., Schmitt, A., Vernier, P., Lesch, K.P., and Bally-Cuif, L. (2012) The ADHD-susceptibility gene lphn3.1 modulates dopaminergic neuron formation and locomotor activity during zebrafish development. Molecular psychiatry. 17(9):946-954
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