Gene
slc7a6
- ID
- ZDB-GENE-000607-21
- Name
- solute carrier family 7 member 6
- Symbol
- slc7a6 Nomenclature History
- Previous Names
-
- id:ibd2834
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable L-lysine:L-arginine antiporter activity and arginine binding activity. Predicted to be involved in several processes, including L-arginine transmembrane transport; glycine betaine transport; and nitric oxide biosynthetic process. Predicted to be located in plasma membrane. Is expressed in ball and yolk syncytial layer. Orthologous to human SLC7A6 (solute carrier family 7 member 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Kudoh et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029317Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa965 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9302 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31575 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Amino acid/polyamine transporter I | Cellular Amino Acid Transporter |
|---|---|---|---|---|
| UniProtKB:Q59I64 | InterPro | 468 | ||
| UniProtKB:F8W255 | InterPro | 494 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc7a6-201
(1)
|
Ensembl | 4,369 nt | ||
| mRNA |
slc7a6-202
(1)
|
Ensembl | 1,423 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-181F22 | ZFIN Curated Data | |
| Encodes | EST | ibd2834 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020474 (1) | 1439 nt | ||
| Genomic | GenBank:CU464087 (2) | 155817 nt | ||
| Polypeptide | UniProtKB:F8W255 (1) | 494 aa |
- Demy, D.L., Carrère, M., Noche, R., Tauzin, M., Le Bris, M., Baek, C., Leshchiner, I., Goessling, W., Herbomel, P. (2020) The cationic amino acid exporter Slc7a7 is induced and vital in tissue macrophages with sustained efferocytic activity. Journal of Cell Science. 133(20):
- Lechermeier, C.G., D'Orazio, A., Romanos, M., Lillesaar, C., Drepper, C. (2020) Distribution of transcripts of the GFOD gene family members gfod1 and gfod2 in the zebrafish central nervous system. Gene expression patterns : GEP. 36:119111
- Benini, A., Cignarella, F., Calvarini, L., Mantovanelli, S., Giacopuzzi, E., Zizioli, D., Borsani, G. (2015) slc7a6os Gene Plays a Critical Role in Defined Areas of the Developing CNS in Zebrafish. PLoS One. 10:e0119696
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chien, Y.W., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC systems biology. 8 Suppl 5:S6
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Kawakami, A., Nojima, Y., Toyoda, A., Takahoko, M., Satoh, M., Tanaka, H., Wada, H., Masai, I., Terasaki, H., Sakaki, Y., Takeda, H., and Okamoto, H. (2005) The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Current biology : CB. 15(5):480-488
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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