Gene

slc40a1

ID
ZDB-GENE-000511-8
Name
solute carrier family 40 member 1
Symbol
slc40a1 Nomenclature History
Previous Names
  • slc39a1 (1)
  • ferroportin1 (1)
  • FPN1
  • weh
  • weissherbst
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Exhibits iron ion transmembrane transporter activity. Involved in several processes, including bone mineralization; hemoglobin biosynthetic process; and hemopoiesis. Predicted to localize to basolateral plasma membrane and integral component of membrane. Used to study iron deficiency anemia. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Is expressed in digestive system; gill; nervous system; solid lens vesicle; and yolk syncytial layer. Orthologous to human SLC40A1 (solute carrier family 40 member 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc40a1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hemochromatosis type 4 Alliance Hemochromatosis, type 4 606069
Associated With slc40a1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR009716 Ferroportin-1
Homologous_superfamily IPR036259 MFS transporter superfamily
Domain Details Per Protein
Protein Length Ferroportin-1 MFS transporter superfamily
UniProtKB:Q0P4F8 255
UniProtKB:Q9I9R3 562
UniProtKB:B0V344 562
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations