Gene
dct
- ID
- ZDB-GENE-000508-1
- Name
- dopachrome tautomerase
- Symbol
- dct Nomenclature History
- Previous Names
-
- TRP-2
- trp2
- tyrosinase-related protein-2
- zgc:109860
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable dopachrome isomerase activity. Acts upstream of or within melanin metabolic process. Predicted to be located in melanosome membrane. Predicted to be active in melanosome. Is expressed in several structures, including eye; female organism; immature eye; integument; and neural crest. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 105 figures from 76 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pennamen et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oculocutaneous albinism, type VIII | 619165 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| oculocutaneous albinism | WT + MO1-dct | standard conditions | Pennamen et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Di-copper centre-containing domain superfamily | Tyrosinase and Hemocyanin | Tyrosinase copper-binding domain |
|---|---|---|---|---|---|
| UniProtKB:A1L1Y0 | InterPro | 513 |
Interactions and Pathways
No data available
Plasmids
No data available