Gene
dct
- ID
- ZDB-GENE-000508-1
- Name
- dopachrome tautomerase
- Symbol
- dct Nomenclature History
- Previous Names
-
- TRP-2
- trp2
- tyrosinase-related protein-2
- zgc:109860
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Is predicted to enable dopachrome isomerase activity. Involved in developmental pigmentation; generation of neurons; and melanin biosynthetic process from tyrosine. Acts upstream of or within melanin biosynthetic process. Predicted to be located in melanosome membrane. Predicted to be integral component of membrane. Is expressed in several structures, including eye; female organism; immature eye; integument; and neural crest. Human ortholog(s) of this gene implicated in oculocutaneous albinism. Orthologous to human DCT (dopachrome tautomerase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 92 figures from 69 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Pennamen et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Oculocutaneous albinism, type VIII | 619165 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| oculocutaneous albinism | WT + MO1-dct | standard conditions | Pennamen et al., 2020 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002227 | Tyrosinase copper-binding domain |
Domain Details Per Protein
| Protein | Length | Tyrosinase copper-binding domain |
|---|---|---|
|
UniProtKB:F1QRR2
|
513 | |
|
UniProtKB:A1L1Y0
|
513 | |
|
UniProtKB:Q9I8G5
|
513 | |
|
UniProtKB:Q4KMK5
|
404 | |
|
UniProtKB:F1QMT0
|
419 |
Interactions and Pathways
No data available
Plasmids
No data available