Gene

fn1a

ID
ZDB-GENE-000426-1
Name
fibronectin 1a
Symbol
fn1a Nomenclature History
Previous Names
  • fn1
  • FN1 (1)
  • fn1l (1)
  • FN2 (1)
  • Fn (1)
  • fb80d10
  • nat
  • natter
  • wu:fb80d10 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Enables integrin binding activity. Acts upstream of or within with a positive effect on pronephric nephron tubule morphogenesis. Acts upstream of or within several processes, including chordate embryonic development; circulatory system development; and epithelial cell differentiation. Located in interstitial matrix. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; tail bud; and yolk. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
72 figures from 34 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fn1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylometaphyseal dysplasia corner fracture type Alliance Spondylometaphyseal dysplasia, corner fracture type 184255
Glomerulopathy with fibronectin deposits 2 601894
1 - 2 of 2
Associated With fn1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000083 Fibronectin, type I
Domain IPR000562 Fibronectin type II domain
Domain IPR003961 Fibronectin type III
Family IPR050991 Extracellular Matrix Regulatory Proteins
Homologous_superfamily IPR013783 Immunoglobulin-like fold
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length Extracellular Matrix Regulatory Proteins Fibronectin, type I Fibronectin type II domain Fibronectin type II domain superfamily Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Kringle-like fold
UniProtKB:A0A8M3B2G8 InterPro 2479
UniProtKB:B0S602 InterPro 2480
1 - 2 of 2
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fn1a-202 (1)
Ensembl
Ensembl 8,776 nt
ZFIN BLAST
mRNA fn1a-203 (1)
Ensembl
Ensembl 135 nt
ZFIN BLAST
ncRNA fn1a-002 (1)
Ensembl
Ensembl 3,022 nt
ZFIN BLAST
1 - 3 of 3
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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