Gene
meis2b
- ID
- ZDB-GENE-000210-23
- Name
- Meis homeobox 2b
- Symbol
- meis2b Nomenclature History
- Previous Names
-
- meis2.1
- meis2
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Acts upstream of or within cardiac atrium morphogenesis and heart looping. Predicted to be located in nucleus. Is expressed in several structures, including anterior neural keel; cardiovascular system; nervous system; neural plate; and optic vesicle. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disability; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to human MEIS2 (Meis homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:76815 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013767Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nju55 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| nju62 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| s988 | Allele with one delins | Unknown | Frameshift, Premature Stop | TALEN | |
| sa23645 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-meis2b | Psutkova et al., 2024 | |
| MO1-meis2b | N/A | Bessa et al., 2008 |
| MO2-meis2b | N/A | Paige et al., 2012 |
| MO3-meis2b | N/A | Paige et al., 2012 |
| MO4-meis2b | N/A | Melvin et al., 2013 |
| TALEN1-meis2b | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cleft palate, cardiac defects, and intellectual disability | Alliance | Cleft palate, cardiac defects, and impaired intellectual development | 600987 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox protein PKNOX/Meis, N-terminal | Homeodomain | KN homeodomain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9DDE0 | InterPro | ||||||
| UniProtKB:Q9PTM7 | InterPro | 393 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
meis2b-201
(1)
|
Ensembl | 3,446 nt | ||
| mRNA |
meis2b-203
(1)
|
Ensembl | 3,104 nt | ||
| ncRNA |
meis2b-002
(1)
|
Ensembl | 843 nt |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(meis2b:GAL4FF) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-277L12 | ZFIN Curated Data | |
| Contained in | BAC | CH73-335N18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:76815 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130910 (1) | 2838 nt | ||
| Genomic | GenBank:CU539064 (2) | 65601 nt | ||
| Polypeptide | UniProtKB:Q9PTM7 (1) | 393 aa |
- Psutkova, V., Nickl, P., Brezinova, V., Machonova, O., Machon, O. (2024) Transcription factor Meis1b regulates craniofacial morphogenesis in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 254(1):40-60
- Dai, Y.T., Zhang, F., Fang, H., Li, J.F., Lu, G., Jiang, L., Chen, B., Mao, D.D., Liu, Y.F., Wang, J., Peng, L.J., Feng, C., Chen, H.F., Mu, J.X., Zhang, Q.L., Wang, H., Ariffin, H., Moy, T.A., Wang, J.H., Lou, Y.J., Chen, S.N., Wang, Q., Liu, H., Shan, Z., Matsumura, I., Miyazaki, Y., Yasuda, T., Dou, L.P., Yan, X.J., Yan, J.S., Yeoh, A.E., Wu, D.P., Kiyoi, H., Hayakawa, F., Jin, J., Wang, S.Y., Sun, X.J., Mi, J.Q., Chen, Z., Huang, J.Y., Chen, S.J. (2022) Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Proceedings of the National Academy of Sciences of the United States of America. 119:e2120787119
- Fabian, P., Tseng, K.C., Thiruppathy, M., Arata, C., Chen, H.J., Smeeton, J., Nelson, N., Crump, J.G. (2022) Lifelong single-cell profiling of cranial neural crest diversification in zebrafish. Nature communications. 13:13
- Wei, G., Zhang, X., Cai, C., Sheng, J., Xu, M., Wang, C., Gu, Q., Guo, C., Chen, F., Liu, D., Qian, F. (2022) Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway. Frontiers in Cellular Neuroscience. 16:840143
- Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
- Wang, M., Du, L., Lee, A.C., Li, Y., Qin, H., He, J. (2020) Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes. The Journal of cell biology. 219(9):
- Witjes, L., Van Troys, M., Vandekerckhove, J., Vandepoele, K., Ampe, C. (2019) A new evolutionary model for the vertebrate actin family including two novel groups. Molecular phylogenetics and evolution. 141:106632
- Barske, L., Rataud, P., Behizad, K., Del Rio, L., Cox, S.G., Crump, J.G. (2018) Essential Role of Nr2f Nuclear Receptors in Patterning the Vertebrate Upper Jaw. Developmental Cell. 44(3):337-347.e5
- Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7
- Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez-Arrones, L., Moreno-Bravo, J.A., Somorjai, I., Pascual-Anaya, J., Puelles, E., Bovolenta, P., Garcia-Fernàndez, J., Puelles, L., Irimia, M., Ferran, J.L. (2017) Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 15:e2001573
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