Gene

robo3

ID
ZDB-GENE-000209-4
Name
roundabout, axon guidance receptor, homolog 3 (Drosophila)
Symbol
robo3 Nomenclature History
Previous Names
  • cb503 (1)
  • twi
  • twitch twice (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have cell-cell adhesion mediator activity. Involved in axonogenesis and determination of ventral identity. Localizes to integral component of plasma membrane. Is expressed in several structures, including EVL; digestive system; fin; nervous system; and neural tube. Orthologous to human ROBO3 (roundabout guidance receptor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
32 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With robo3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Gaze palsy, familial horizontal, with progressive scoliosis, 1 607313
Associated With robo3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013106 Immunoglobulin V-set domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Immunoglobulin V-set domain
UniProtKB:Q98SW3 1419
UniProtKB:Q90Z69 1389
UniProtKB:A0A2R8QRK0 1420
UniProtKB:A4JYD3 956
UniProtKB:A8DZ85 1389
UniProtKB:F1QFK4 1419
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations