Gene

calr3a

ID

ZDB-GENE-000208-17

Name

calreticulin 3a

Symbol

calr3a Nomenclature History

Previous Names

calr
zgc:85636

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in cell surface; cortical granule; and sarcoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including axis; cardiovascular system; hatching gland; periderm; and polster. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to several human genes including CALR3 (calreticulin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:66084 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hung et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With calr3a Human Ortholog

No data available

Associated With calr3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018124	Calreticulin/calnexin, conserved site
Family	IPR001580	Calreticulin/calnexin
Family	IPR009169	Calreticulin
Homologous_superfamily	IPR009033	Calreticulin/calnexin, P domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily