ZFIN is now using GRCz12tu for Genomic Data
Gene
dlc
- ID
- ZDB-GENE-000125-4
- Name
- deltaC
- Symbol
- dlc Nomenclature History
- Previous Names
-
- bea
- beamter
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables PDZ domain binding activity and identical protein binding activity. Acts upstream of or within several processes, including blood vessel development; neuron differentiation; and somite development. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including immature eye; integument; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 180 figures from 112 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d401 (20 images)
- eu289 (26 images)
- eu238 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 1 | Alliance | Spondylocostal dysostosis 1, autosomal recessive | 277300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4JYS0 | InterPro | 664 | ||||||||
| UniProtKB:Q9IAT6 | InterPro | 664 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available
- Genome Browsers