ZFIN Fish: tp53^zdf1/zdf1; nn1002Tg; nn1003Tg

ZFIN ID: ZDB-FISH-201201-4

ZFIN ID: ZDB-FISH-201201-4

Fish name:	tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Genotype:	tp53^zdf1/zdf1; nn1002Tg; nn1003Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by tp53^zdf1/zdf1; nn1002Tg; nn1003Tg

Human Disease	Conditions	Citations
hepatocellular carcinoma	control	Yang et al., 2019

GENE EXPRESSION
Gene expression in tp53^zdf1/zdf1; nn1002Tg; nn1003Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
acat2	liver	control	Figure 7 from Yang et al., 2019
	liver	increased food availability	Figure 7 from Yang et al., 2019
aldh7a1	liver	control	Figure 7 from Yang et al., 2019
	liver	increased food availability	Figure 7 from Yang et al., 2019
ccne1	liver	increased food availability	Figure 2 from Yang et al., 2019
cdk1	liver	increased food availability	Figure 2 from Yang et al., 2019
cdk2	liver	increased food availability	Figure 2 from Yang et al., 2019
gck	liver	control	Figure 7 from Yang et al., 2019
pik3ca	liver	control	Figure 7 from Yang et al., 2019
	liver	increased food availability	Figure 7 from Yang et al., 2019
scd	liver	control	Figure 7 from Yang et al., 2019
	liver	increased food availability	Figure 7 from Yang et al., 2019
srebf1	liver	increased food availability	Figure 2 from Yang et al., 2019

Protein expression No data available

Reporter gene expression No data available

PHENOTYPE
Phenotype in tp53^zdf1/zdf1; nn1002Tg; nn1003Tg

Phenotype	Conditions	Figures
female organism increased weight, abnormal	increased food availability	Fig. S1 from Yang et al., 2019
liver aldh7a1 expression decreased amount, abnormal	increased food availability	Figure 7 from Yang et al., 2019
liver aldh7a1 expression decreased amount, abnormal	control	Figure 7 from Yang et al., 2019
liver pik3ca expression decreased amount, abnormal	control	Figure 7 from Yang et al., 2019
liver scd expression decreased amount, abnormal	increased food availability	Figure 7 from Yang et al., 2019
liver acat2 expression decreased amount, abnormal	increased food availability	Figure 7 from Yang et al., 2019
liver gck expression decreased amount, abnormal	control	Figure 7 from Yang et al., 2019
liver pik3ca expression decreased amount, abnormal	increased food availability	Figure 7 from Yang et al., 2019
liver hyperplastic, abnormal	control	Figure 3 , Figure 4 from Yang et al., 2019
liver hyperplastic, abnormal	increased food availability	Figure 4 from Yang et al., 2019
liver hyperplastic, exacerbated	increased food availability	Figure 3 from Yang et al., 2019
liver cdk1 expression increased amount, abnormal	increased food availability	Figure 2 from Yang et al., 2019
liver ccne1 expression increased amount, abnormal	increased food availability	Figure 2 from Yang et al., 2019
liver aldh7a1 expression increased amount, abnormal	control	Figure 7 from Yang et al., 2019
liver cdk2 expression increased amount, abnormal	increased food availability	Figure 2 from Yang et al., 2019
liver scd expression increased amount, abnormal	control	Figure 7 from Yang et al., 2019
liver acat2 expression increased amount, abnormal	control	Figure 7 from Yang et al., 2019
liver srebf1 expression increased amount, abnormal	increased food availability	Figure 2 from Yang et al., 2019
liver aldh7a1 expression increased amount, abnormal	increased food availability	Figure 7 from Yang et al., 2019
liver acat2 expression increased amount, abnormal	increased food availability	Figure 7 from Yang et al., 2019
liver hepatocellular carcinoma increased amount, abnormal	control	Figure 3 , Figure 4 from Yang et al., 2019
liver hepatocellular carcinoma increased amount, exacerbated	increased food availability	Figure 3 , Figure 4 from Yang et al., 2019
liver hepatocyte morphology, abnormal	control	Figure 3 , Figure 4 from Yang et al., 2019
liver hepatocyte morphology, abnormal	increased food availability	Figure 3 from Yang et al., 2019
liver lipid increased amount, abnormal	increased food availability	Figure 4 from Yang et al., 2019
liver lipid increased amount, abnormal	control	Figure 4 from Yang et al., 2019
male organism increased weight, abnormal	increased food availability	Fig. S1 from Yang et al., 2019
whole organism increased weight, abnormal	increased food availability	Fig. S1 from Yang et al., 2019

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