ZFIN Fish: tp53^zdf1/zdf1; nn1002Tg; nn1004Tg

ZFIN ID: ZDB-FISH-200401-1

ZFIN ID: ZDB-FISH-200401-1

Fish name:	tp53^zdf1/zdf1; nn1002Tg; nn1004Tg
Genotype:	tp53^zdf1/zdf1; nn1002Tg; nn1004Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by tp53^zdf1/zdf1; nn1002Tg; nn1004Tg

Human Disease	Conditions	Citations
hepatocellular carcinoma	control	Lin et al., 2019

GENE EXPRESSION
Gene expression in tp53^zdf1/zdf1; nn1002Tg; nn1004Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
ccne1	liver	increased food availability	Fig. 7 from Lin et al., 2019
cdk1	liver	increased food availability	Fig. 7 from Lin et al., 2019
cdk2	liver	increased food availability	Fig. 7 from Lin et al., 2019

Protein expression No data available

Reporter gene expression No data available

PHENOTYPE
Phenotype in tp53^zdf1/zdf1; nn1002Tg; nn1004Tg

Phenotype	Conditions	Figures
liver ccne1 expression amount, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver cdk1 expression amount, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver cdk2 expression amount, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver dysplastic, exacerbated	increased food availability	Fig. 7 from Lin et al., 2019
liver hyperplastic, exacerbated	increased food availability	Fig. 7 from Lin et al., 2019
liver cdk1 expression increased amount, abnormal	increased food availability	Fig. 7 from Lin et al., 2019
liver ccne1 expression increased amount, abnormal	increased food availability	Fig. 7 from Lin et al., 2019
liver cdk2 expression increased amount, abnormal	increased food availability	Fig. 7 from Lin et al., 2019
liver structure, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver cell population proliferation increased occurrence, abnormal	increased food availability	Fig. 7 from Lin et al., 2019
liver cell population proliferation occurrence, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver hepatocellular carcinoma amount, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver hepatocellular carcinoma increased amount, exacerbated	increased food availability	Fig. 7 from Lin et al., 2019
liver lipid amount, ameliorated	chemical treatment by gavage: EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, increased food availability	Fig. 7 from Lin et al., 2019
liver lipid increased amount, exacerbated	increased food availability	Fig. 7 from Lin et al., 2019

CITATIONS (1)