ZFIN Fish: mmc1Tg

ZFIN ID: ZDB-FISH-200116-10

Fish name:	mmc1Tg
Genotype:	mmc1Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by mmc1Tg

Human Disease	Conditions	Citations
amyotrophic lateral sclerosis	chemical treatment by environment: doxycycline	Lin et al., 2018

GENE EXPRESSION
Gene expression in mmc1Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
rtn4a	muscle	chemical treatment by environment: doxycycline	Fig. 2 from Lin et al., 2018

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab-SV2		motor neuron synaptic vesicle	control	Fig. 3 from Lin et al., 2018
Ab-SV2		motor neuron synaptic vesicle	chemical treatment by environment: doxycycline	Fig. 3 from Lin et al., 2018

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
DsRed	(not) muscle cell	control	Fig. 2 from Lin et al., 2018
	muscle cell	chemical treatment by environment: doxycycline	Fig. 2 from Lin et al., 2018

PHENOTYPE
Phenotype in mmc1Tg

Phenotype	Conditions	Figures
muscle rtn4a expression increased amount, abnormal	chemical treatment by environment: doxycycline	Fig. 2 from Lin et al., 2018
muscle cell morphology, abnormal	chemical treatment by environment: doxycycline	Fig. 4 from Lin et al., 2018
muscle cell split, abnormal	chemical treatment by environment: doxycycline	Fig. 4 from Lin et al., 2018
neuromuscular junction development, skeletal muscle fiber process quality, abnormal	chemical treatment by environment: doxycycline	Fig. 3 from Lin et al., 2018
skeletal muscle neuromuscular junction decreased stability, abnormal	chemical treatment by environment: doxycycline	Fig. 3 from Lin et al., 2018
swimming decreased process quality, abnormal	chemical treatment by environment: doxycycline	Fig. 6 from Lin et al., 2018
ventral horn spinal cord motor neuron decreased amount, abnormal	chemical treatment by environment: doxycycline	Fig. 7 from Lin et al., 2018
whole organism decreased weight, abnormal	chemical treatment by environment: doxycycline	Fig. 5 from Lin et al., 2018
whole organism decreased width, abnormal	chemical treatment by environment: doxycycline	Fig. 5 from Lin et al., 2018

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