ZFIN ID: ZDB-FISH-170823-11
Fish name: TL + MO1-cln3
Genotype: TL
Targeting Reagent: MO1-cln3
HUMAN DISEASE MODELED by TL + MO1-cln3
Human Disease Conditions Citations
neuronal ceroid lipofuscinosis 3 standard conditions Wager et al., 2016
GENE EXPRESSION
Gene expression in TL + MO1-cln3
RNA expression No data available
Protein expression No data available
Reporter gene expression No data available
PHENOTYPE
Phenotype in TL + MO1-cln3
Phenotype Conditions Figures
apoptotic process increased occurrence, abnormal standard conditions Fig. 8 with image from Wager et al., 2016
axon extension disrupted, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
brain morphology, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
brain astrocyte increased amount, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
brain axon aggregated, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
brain axon disorganized, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
brain cell apoptotic, abnormal standard conditions Fig. 8 with image from Wager et al., 2016
brain lysosome hypertrophic, abnormal standard conditions Fig. 8 with image from Wager et al., 2016
brain development disrupted, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
cranial nerve II decreased width, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
eye mitochondrion morphology, abnormal standard conditions Fig. 9 with image from Wager et al., 2016
forebrain apoptotic body increased amount, abnormal standard conditions Fig. 8 with image from Wager et al., 2016
fourth ventricle increased size, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
hindbrain size, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
larval locomotory behavior process quality, abnormal standard conditions Fig. 5 from Wager et al., 2016
midbrain decreased size, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
optic tectum axon absent, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
optic tectum regulation of neuronal action potential disrupted, abnormal standard conditions Fig. 4 from Wager et al., 2016
pericardium increased size, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
post-vent region curved, abnormal standard conditions Fig. 3 with image from Wager et al., 2016
regulation of mitochondrial membrane potential disrupted, abnormal standard conditions Fig. 9 with image from Wager et al., 2016
retina decreased size, abnormal standard conditions Fig. 3 with imageFig. 7 with image from Wager et al., 2016
retina cell apoptotic, abnormal standard conditions Fig. 8 with image from Wager et al., 2016
retina cell population proliferation disrupted, abnormal standard conditions Fig. 7 with image from Wager et al., 2016
spinal cord astrocyte increased amount, abnormal standard conditions Fig. 6 with image from Wager et al., 2016
whole organism dead, abnormal standard conditions Fig. 5 from Wager et al., 2016
whole organism decreased life span, abnormal standard conditions Fig. 5 from Wager et al., 2016
whole organism lysosome increased size, abnormal standard conditions Fig. 9 with image from Wager et al., 2016
whole organism thigmotaxis disrupted, abnormal standard conditions Fig. 5 from Wager et al., 2016
yolk increased size, abnormal standard conditions Fig. 3 with image from Wager et al., 2016

CITATIONS  (1)