ZFIN ID: ZDB-FISH-150901-4627
Fish name: WT + MO1-smn1
Genotype: WT
Targeting Reagent: MO1-smn1
HUMAN DISEASE MODELED by WT + MO1-smn1
Human Disease Conditions Citations
spinal muscular atrophy standard conditions (4)
GENE EXPRESSION
Gene expression in WT + MO1-smn1
RNA expression
Expressed Gene Structure Conditions Figures
smn1 standard conditions Fig. 5Fig. 6 from Winkler et al., 2005
Reporter gene expression No data available
PHENOTYPE
Phenotype in WT + MO1-smn1
Phenotype Conditions Figures
axon extension process quality, abnormal standard conditions Fig. 7 with image from Chitramuthu et al., 2010
axonogenesis disrupted, abnormal standard conditions Fig. 4 from Oprea et al., 2008
CaP motoneuron axon branched, abnormal standard conditions Fig. 4 from See et al., 2014
Fig. 7 with image from Chitramuthu et al., 2010
CaP motoneuron axon decreased length, abnormal standard conditions Fig. 7 with image from Chitramuthu et al., 2010
CaP motoneuron axon truncated, abnormal standard conditions Fig. 4 from See et al., 2014
motor neuron axon branchiness, abnormal standard conditions Fig. 5 from Winkler et al., 2005
motor neuron axon morphology, abnormal standard conditions Fig. 4 from Oprea et al., 2008
motor neuron axon truncated, abnormal standard conditions Fig. 5 from Winkler et al., 2005
mRNA splicing, via spliceosome decreased process quality, abnormal standard conditions Fig. 2 from See et al., 2014
primary motor neuron axon decreased length, abnormal standard conditions Fig. 5 with image from Boyd et al., 2017
primary motor neuron axon terminus swollen, abnormal standard conditions Fig. 5 with image from Boyd et al., 2017
primary motor neuron axonogenesis disrupted, abnormal standard conditions Fig. 5 with image from Boyd et al., 2017
whole organism Ab2-atp5a labeling decreased amount, abnormal standard conditions Fig. 2 from Boyd et al., 2017
whole organism aerobic respiration decreased efficacy, abnormal standard conditions Fig. 2 from Boyd et al., 2017
whole organism ATP generation from ADP decreased efficacy, abnormal standard conditions Fig. 2 from Boyd et al., 2017
whole organism mitochondrion decreased functionality, abnormal standard conditions Fig. 2 from Boyd et al., 2017

CITATIONS  (8)