ZFIN Fish: vhl^hu2081/+; vhl^hu2117/+

ZFIN ID: ZDB-FISH-150901-348

ZFIN ID: ZDB-FISH-150901-348

Fish name:	vhl^hu2081/+; vhl^hu2117/+
Genotype:	vhl^hu2081/+; vhl^hu2117/+
Targeting Reagent:	none

HUMAN DISEASE MODELED by vhl^hu2081/+; vhl^hu2117/+

Human Disease	Conditions	Citations
familial erythrocytosis 2	standard conditions	van Rooijen et al., 2009

GENE EXPRESSION
Gene expression in vhl^hu2081/+; vhl^hu2117/+

RNA expression

Expressed Gene	Structure	Conditions	Figures
cxcr4a	brain vasculature mesonephric podocyte ocular blood vessel (not) optic choroid vascular plexus	standard conditions	Fig. 3, Fig. S1 from van Rooijen et al., 2010
cxcr4b	(not) brain vasculature head kidney (not) ocular blood vessel	standard conditions	Fig. S1 from van Rooijen et al., 2010
egln3	heart whole organism	standard conditions	Fig. 2, Fig. 7 from van Rooijen et al., 2009
epoa	liver renal glomerulus	standard conditions	Fig. 2, Fig. 7 from van Rooijen et al., 2009
epor	liver renal glomerulus	standard conditions	Fig. 2, Fig. 7 from van Rooijen et al., 2009
flt1	whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2010
flt4	whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2010
gata1a	erythroid progenitor cell	standard conditions	Fig. 4 from van Rooijen et al., 2009
hbbe1.1	nucleate erythrocyte	standard conditions	Fig. 4, Fig. 7 from van Rooijen et al., 2009
ikzf1	common lymphoid progenitor	standard conditions	Fig. 4 from van Rooijen et al., 2009
kdr	blood vasculature liver renal glomerulus whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2010 Fig. 2 from van Rooijen et al., 2009
kdrl	blood vasculature liver renal glomerulus whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2010 Fig. 2 from van Rooijen et al., 2009
lck	lymphocyte	standard conditions	Fig. 4 from van Rooijen et al., 2009
lcp1	macrophage monocyte	standard conditions	Fig. 4, Fig. S3 from van Rooijen et al., 2009
ldha	whole organism	standard conditions	Fig. 2 from van Rooijen et al., 2009
mcm5	anatomical structure	standard conditions	Fig. 1 from Mans et al., 2013
mpx	neutrophil	standard conditions	Fig. 4 from van Rooijen et al., 2009
myb	hematopoietic stem cell	standard conditions	Fig. 3, Fig. 4 from van Rooijen et al., 2009
ndufa4b	heart whole organism	standard conditions	Fig. 2, Fig. 7 from van Rooijen et al., 2009
slc2a1a	liver	standard conditions	Fig. 2 from van Rooijen et al., 2009
tal1	hematopoietic stem cell nucleate erythrocyte	standard conditions	Fig. 4 from van Rooijen et al., 2009
vegfaa	brain endocrine pancreas head kidney mesonephric podocyte renal glomerulus retina whole organism	standard conditions	Fig. 1, Fig. S1 from van Rooijen et al., 2010 Fig. 2, Fig. 7 from van Rooijen et al., 2009
vegfab	whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2010
vegfc	whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2010
vhl	(not) whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2009

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab1-stat5		whole organism	standard conditions	Fig. 2 from van Rooijen et al., 2009
Ab2-stat5		whole organism	standard conditions	Fig. 2 from van Rooijen et al., 2009
Ab2-lcp1	lcp1	macrophage	standard conditions	Fig. S3 from van Rooijen et al., 2009
Ab1-vhl	vhl	(not) whole organism	standard conditions	Fig. 1 from van Rooijen et al., 2009

Reporter gene expression No data available

PHENOTYPE
Phenotype in vhl^hu2081/+; vhl^hu2117/+

Phenotype	Conditions	Figures
angiogenesis increased occurrence, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2010
heart contraction increased rate, abnormal	standard conditions	Fig. 2 from van Rooijen et al., 2009
hematopoietic stem cell increased amount, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2009
macrophage increased amount, abnormal	standard conditions	Fig. S3 from van Rooijen et al., 2009
nucleate erythrocyte increased amount, abnormal	standard conditions	Fig. 3, Fig. 5 from van Rooijen et al., 2009
nucleate erythrocyte optical quality, abnormal	standard conditions	Fig. 5 from van Rooijen et al., 2009
ocular blood vessel branched, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2010
ocular blood vessel malformed, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2010
pronephric podocyte physical object quality, abnormal	standard conditions	Fig. S1 from van Rooijen et al., 2010
regulation of vascular endothelial growth factor receptor signaling pathway process quality, abnormal	standard conditions	Fig. 1 from van Rooijen et al., 2010
retina deformed, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2010
retina edematous, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2010
retinal inner plexiform layer ocular blood vessel mislocalised, abnormal	standard conditions	Fig. 3 from van Rooijen et al., 2010

CITATIONS (6)