ZFIN Fish: s870Tg

ZFIN ID: ZDB-FISH-150901-29329

ZFIN ID: ZDB-FISH-150901-29329

Fish name:	s870Tg
Genotype:	s870Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by s870Tg
No data available

GENE EXPRESSION
Gene expression in s870Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
anxa4	anterior pancreatic bud intestinal bulb primordium intestinal rod liver pancreas pancreas primordium pancreatic bud posterior pancreatic bud pronephric duct	standard conditions	Fig. 1 , Fig. 2 , Fig. 3 , Fig. 5 from Zhang et al., 2014
arrb1	(not) endoderm	standard conditions	Fig. 6 from Burczyk et al., 2015
arrb2b	endoderm	standard conditions	Fig. 6 from Burczyk et al., 2015
cdh1	forerunner cell group whole organism	standard conditions	Fig. 4, Fig. 6 from Wang et al., 2017
cxcr4b	forerunner cell group	standard conditions	Fig. 7 from Jiang et al., 2019
dkk1b	whole organism	standard conditions	Fig. 4 from Wang et al., 2017
dmrt2b	pharyngeal pouch 1 pharyngeal pouch 2 pharyngeal pouch 3 pharyngeal pouch 4 pharyngeal pouch 5 pharyngeal pouch 6	standard conditions	Fig. 1 from Li et al., 2018
dusp6	whole organism	standard conditions	Fig. 4 from Wang et al., 2017
fgf8a	whole organism	standard conditions	Fig. 4 from Wang et al., 2017
fhl1b	endoderm anterior region liver primordium posterior pancreatic bud	standard conditions	Fig. 1 from Xu et al., 2016
foxa3	endodermal cell	standard conditions	Fig. S5 from Lu et al., 2013
gata5	whole organism	standard conditions	Fig. 4 from Wang et al., 2017
grk3	endoderm	standard conditions	Fig. 6 from Burczyk et al., 2015
id1	liver (not) pancreatic bud	standard conditions	Fig. 2 from Khaliq et al., 2015
id2a	interrenal primordium	standard conditions	Fig. S2 from Khaliq et al., 2015
id3	whole organism	standard conditions	Fig. 4 from Wang et al., 2017
insrb	intestine liver pancreas	standard conditions	Fig. 1 from Ye et al., 2016
kremen1	endodermal cell	standard conditions	Fig. S5 from Lu et al., 2013
lft2	forerunner cell group whole organism	standard conditions	Fig. 4 from Wang et al., 2017
otx2b	(not) endodermal cell	standard conditions	Fig. S5 from Lu et al., 2013
pdx1	pancreas primordium	standard conditions	Fig. 3 from Chung et al., 2008
pitx2	whole organism	standard conditions	Fig. 4 from Wang et al., 2017
s1pr2	endoderm	standard conditions	Fig. 6 from Burczyk et al., 2015
tbxta	presumptive mesoderm whole organism	standard conditions	Fig. 4 from Wang et al., 2017 Fig. 3 from Cheng et al., 2013

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab2-fn		endoderm extracellular matrix	standard conditions	Fig. 7 from Collins et al., 2018
Ab2-ins		endocrine pancreas	standard conditions	Fig. 1 from Chung et al., 2008
Ab1-prkca		Kupffer's vesicle apical plasma membrane	standard conditions	Fig. 4 from Navis et al., 2013
Ab2-isl		insulin secreting cell	control	Fig. 2 , Fig. 5 from Xu et al., 2016
Ab18-h3		Kupffer's vesicle	standard conditions	Fig. 2 from Arrington et al., 2013
Ab1-5-mC		forerunner cell group nucleus	standard conditions	Figure 10 from Fillatre et al., 2019 Fig. 1 from Wang et al., 2017
Ab1-tjp1		forerunner cell group bicellular tight junction Kupffer's vesicle	standard conditions	Fig. 2 , Fig. 3 , Fig. 4 from Oteíza et al., 2008
Ab1-atp6ap1		forerunner cell group plasma membrane	control	Fig. 1 from Gokey et al., 2015
Ab1-tuba		Kupffer's vesicle cilium	standard conditions	Fig. 5 from Lin et al., 2017 Fig. 2 , Fig. 5 from Tay et al., 2013 Fig. 3 , Fig. 4 from Oteíza et al., 2008
Ab3-h3		anatomical structure forerunner cell group	control	Fig. 8 from Gokey et al., 2015
Ab1-prkcz		forerunner cell group bicellular tight junction Kupffer's vesicle	standard conditions	Fig. 4 from Pelliccia et al., 2017 Fig. 2 from Zhang et al., 2016 Fig. 4 from Oteíza et al., 2008
Ab1-cldn5		forerunner cell group Kupffer's vesicle	standard conditions	Fig. 1 , Fig. S2 from Kim et al., 2017
Ab3-prkcz		Kupffer's vesicle anatomical space	control	Fig. 2 , Fig. 7 from Gao et al., 2017
Ab4-atp6v1a		forerunner cell group cytoplasm	control	Fig. 7 from Gokey et al., 2015
Ab2-smad3		pharyngeal arch anatomical region	standard conditions	Fig. 5 , Fig. S4 from Abrial et al., 2017
Ab-2F11	anxa4	anterior pancreatic bud intestinal bulb primordium intestinal rod liver pancreas pancreas primordium pancreatic bud posterior pancreatic bud pronephric duct	standard conditions	Fig. 1 , Fig. 2 , Fig. 3 , Fig. 5 from Zhang et al., 2014

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	Kupffer's vesicle	standard conditions	Fig. 8 from Rosenfeld et al., 2013
GFP	anterior pancreatic bud endocrine pancreas endoderm endodermal cell exocrine pancreas forerunner cell group intestinal bulb intestinal bulb primordium intestinal rod intestine Kupffer's vesicle liver liver primordium pancreas pancreatic bud pharyngeal pouch pharyngeal pouch 1 pharyngeal pouch 2 pharyngeal pouch 3 pharyngeal pouch 4 pharyngeal pouch 5 pharyngeal pouch 6 pharyngeal pouches 2-6 posterior pancreatic bud presumptive endoderm	standard conditions	53 figures from 27 publications
	Kupffer's vesicle	chemical treatment: ouabain	Fig. 7 from Navis et al., 2013

PHENOTYPE
Phenotype in s870Tg

Phenotype	Conditions	Figures
Kupffer's vesicle decreased area, abnormal	chemical treatment: ouabain	Fig. 7 from Navis et al., 2013
Kupffer's vesicle increased area, abnormal	chemical treatment: 3-isobutyl-1-methylxanthine, chemical treatment: forskolin	Fig. 7 from Navis et al., 2013
P-type sodium:potassium-exchanging transporter activity decreased occurrence, abnormal	chemical treatment: ouabain	Fig. 7 from Navis et al., 2013
protein kinase A signaling increased occurrence, abnormal	chemical treatment: 3-isobutyl-1-methylxanthine, chemical treatment: forskolin	Fig. 7 from Navis et al., 2013

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