ZFIN Fish: rw021Tg

ZFIN ID: ZDB-FISH-150901-22020

Fish name:	rw021Tg
Genotype:	rw021Tg
Targeting Reagent:	none

HUMAN DISEASE MODELED by rw021Tg
No data available

GENE EXPRESSION
Gene expression in rw021Tg

RNA expression

Expressed Gene	Structure	Conditions	Figures
alcama	heart tube retina	heat shock	Fig. 1 from Kay et al., 2005
atoh7	retina retinal ganglion cell	standard conditions	Fig. 1 from Poggi et al., 2005

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab1-pax6		amacrine cell retinal ganglion cell	standard conditions	Fig. 2 from Imai et al., 2014
zpr-1		eye photoreceptor cell retinal cone cell retinal outer nuclear layer	standard conditions	Fig. 2 from Imai et al., 2014 Fig. 2 from Poggi et al., 2005
zn-5		retinal ganglion cell	standard conditions	Fig. 2 from Imai et al., 2014 Fig. 2 from Poggi et al., 2005

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
GFP	amacrine cell cranial nerve II eye photoreceptor cell horizontal cell optic cup optic tectum neuron projection retina (not) retinal bipolar neuron retinal ganglion cell retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer	standard conditions	16 figures from 10 publications
	cranial nerve II optic cup optic tectum retina retinal ganglion cell layer retinal inner nuclear layer retinal outer nuclear layer	chemical treatment: drug	Fig. 1 from Weaver et al., 2018 Fig. 7 from Valdivia et al., 2016 Fig. 9, Fig. 10 from Conner et al., 2014

PHENOTYPE
Phenotype in rw021Tg

Phenotype	Conditions	Figures
cranial nerve II decreased thickness, abnormal	chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
cranial nerve II thickness, ameliorated	chemical treatment by environment: hydrogen peroxide, chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
optic cup GFP expression increased amount, abnormal	chemical treatment: 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid	Fig. 7 from Valdivia et al., 2016
optic tectum GFP expression decreased distribution, abnormal	chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
optic tectum GFP expression spatial pattern, ameliorated	chemical treatment by environment: hydrogen peroxide, chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
optic tectum innervation decreased occurrence, abnormal	chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
optic tectum innervation occurrence, ameliorated	chemical treatment by environment: hydrogen peroxide, chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
retina GFP expression increased amount, abnormal	chemical treatment: 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid	Fig. 7 from Valdivia et al., 2016
retina GFP expression increased distribution, abnormal	chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
retina GFP expression increased distribution, abnormal	chemical treatment by environment: hydrogen peroxide, chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
retina apoptotic process occurrence, normal	chemical treatment: purpurogallin, chemical treatment: double-stranded DNA fragment	Fig. 10 from Conner et al., 2014
retinal ganglion cell layer increased width, abnormal	chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
retinal ganglion cell layer increased width, abnormal	chemical treatment by environment: hydrogen peroxide, chemical treatment by environment: celastrol	Fig. 1 from Weaver et al., 2018
retinal inner nuclear layer cell population proliferation increased occurrence, abnormal	chemical treatment: purpurogallin, chemical treatment: double-stranded DNA fragment	Fig. 9 from Conner et al., 2014
retinal inner nuclear layer neuron differentiation increased occurrence, abnormal	chemical treatment: purpurogallin, chemical treatment: double-stranded DNA fragment	Fig. 9 from Conner et al., 2014

CITATIONS (28)