ZFIN Fish: npas4l^s5/s5

ZFIN ID: ZDB-FISH-150901-21185

ZFIN ID: ZDB-FISH-150901-21185

Fish name:	npas4l^s5/s5
Genotype:	npas4l^s5/s5
Targeting Reagent:	none

HUMAN DISEASE MODELED by npas4l^s5/s5
No data available

GENE EXPRESSION
Gene expression in npas4l^s5/s5

RNA expression

Expressed Gene	Structure	Conditions	Figures
acta2	dorsal aorta smooth muscle	standard conditions	Fig. S4 from Santoro et al., 2009
dnmt3bb.1	(not) hematopoietic stem cell (not) ventral wall of dorsal aorta	standard conditions	Fig. 4 from Takayama et al., 2014
erg	(not) anterior lateral mesoderm (not) posterior lateral mesoderm	standard conditions	Fig. S6 from Liu et al., 2008
etsrp	(not) anterior lateral mesoderm intermediate cell mass of mesoderm (not) posterior lateral mesoderm	standard conditions	Fig. S4 from Reischauer et al., 2016 Fig. S6 from Liu et al., 2008
fli1	(not) anterior lateral mesoderm posterior lateral mesoderm	standard conditions	Fig. S6 from Liu et al., 2008
flt3	(not) ball anterior region	standard conditions	Fig. 1, Fig. S4 from He et al., 2014
gata1a	intermediate cell mass of mesoderm	standard conditions	Fig. S4 from Reischauer et al., 2016
gata2a	(not) posterior lateral mesoderm	standard conditions	Fig. S6 from Liu et al., 2008
gata4	anterior lateral plate mesoderm	standard conditions	Fig. 5 from Schoenebeck et al., 2007
hand2	anterior lateral plate mesoderm	standard conditions	Fig. 5 from Schoenebeck et al., 2007
hbae1.1	(not) intermediate cell mass of mesoderm	standard conditions	Fig. 1, Fig. S4 from He et al., 2014
hbbe1.1	erythroid lineage cell post-vent region erythroid lineage cell	standard conditions	Fig. 2 , Fig. 4 from Ma et al., 2011
id4	(not) endocardium (not) heart	control	Fig. 1 from Ahuja et al., 2016
kdrl	blood vessel endothelial cell post-vent region endothelial cell trunk endothelial cell	standard conditions	Fig. 1 from Ma et al., 2011
lcp1	(not) myeloid cell (not) post-vent region myeloid cell	standard conditions	Fig. 3 , Fig. 4 from Ma et al., 2011
myb	(not) post-vent region hematopoietic stem cell (not) ventral wall of dorsal aorta hematopoietic stem cell	standard conditions	Fig. 4 from Ma et al., 2011
myl7	cardiac muscle cell heart heart tube	standard conditions	Fig. 2 from Holtzman et al., 2007 Fig. 5 , Fig. S1 from Schoenebeck et al., 2007
nkx2.5	cardiac muscle cell	standard conditions	Fig. S1 from Schoenebeck et al., 2007
rag1	(not) thymus T cell	standard conditions	Fig. 4 from Ma et al., 2011
sox7	(not) anterior lateral plate mesoderm (not) blood vasculature (not) posterior lateral plate mesoderm	standard conditions	Fig. 2 from Cermenati et al., 2008
sox18	(not) anterior lateral plate mesoderm (not) blood vasculature (not) posterior lateral plate mesoderm	standard conditions	Fig. 2 from Cermenati et al., 2008
tagln	dorsal aorta smooth muscle	standard conditions	Fig. S3 from Santoro et al., 2009
tal1	(not) anterior lateral mesoderm intermediate cell mass of mesoderm (not) posterior lateral mesoderm (not) whole organism	standard conditions	Fig. S4 from Reischauer et al., 2016 Fig. 4 , Fig. S6 from Liu et al., 2008 Fig. 7 from Qian et al., 2007
tm4sf18	(not) dorsal aorta	standard conditions	Fig. 3 from Page et al., 2019

Protein expression No data available

Reporter gene expression No data available

PHENOTYPE
Phenotype in npas4l^s5/s5

Phenotype	Conditions	Figures
anterior lateral mesoderm morphology, abnormal	standard conditions	Fig. S6 from Liu et al., 2008
anterior lateral plate mesoderm morphology, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
atrium dilated, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
atrium increased size, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
atrium cardiac muscle cell increased amount, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
axial vasculature aplastic, abnormal	standard conditions	Fig. 1 from Ma et al., 2011
blood circulation disrupted, abnormal	standard conditions	Fig. S1 from Ma et al., 2011
blood circulation process quality, abnormal	heat shock	Fig. 3 from Ahuja et al., 2016
blood vessel endothelial cell decreased amount, abnormal	standard conditions	Fig. 1 from Ma et al., 2011
cardiac muscle cell mislocalised, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
cardiac ventricle decreased size, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
definitive hemopoiesis arrested, abnormal	standard conditions	Fig. 4 from Ma et al., 2011
dorsal aorta tm4sf18 expression absent, abnormal	standard conditions	Fig. 3 from Page et al., 2019
embryonic hemopoiesis disrupted, abnormal	standard conditions	Fig. 4 , Fig. S6 from Liu et al., 2008
endocardium id4 expression absent, abnormal	control	Fig. 1 from Ahuja et al., 2016
erythroid lineage cell decreased amount, abnormal	standard conditions	Fig. 4 from Ma et al., 2011
heart id4 expression absent, abnormal	control	Fig. 1 from Ahuja et al., 2016
heart decreased strength, abnormal	standard conditions	Fig. S1 from Ma et al., 2011
heart contraction decreased magnitude, abnormal	standard conditions	Fig. S1 from Ma et al., 2011
heart looping disrupted, abnormal	standard conditions	Fig. 5 from Schoenebeck et al., 2007
heart tube decreased length, abnormal	standard conditions	Fig. 2 from Holtzman et al., 2007
heart tube increased width, abnormal	standard conditions	Fig. 2 from Holtzman et al., 2007
hematopoietic stem cell absent, abnormal	standard conditions	Fig. 4 from Ma et al., 2011
hematopoietic stem cell differentiation disrupted, abnormal	standard conditions	Fig. 4 from Takayama et al., 2014
intermediate cell mass of mesoderm etsrp expression decreased amount, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
intermediate cell mass of mesoderm gata1a expression decreased amount, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
intermediate cell mass of mesoderm tal1 expression decreased amount, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
intermediate cell mass of mesoderm gata1a expression decreased distribution, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
intermediate cell mass of mesoderm etsrp expression decreased distribution, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
intermediate cell mass of mesoderm tal1 expression decreased distribution, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
intermediate cell mass of mesoderm decreased size, abnormal	standard conditions	Fig. S4 from Reischauer et al., 2016
myeloid cell absent, abnormal	standard conditions	Fig. 3 , Fig. 4 from Ma et al., 2011
pericardium edematous, abnormal	standard conditions	Fig. S1 from Ma et al., 2011
posterior lateral mesoderm morphology, abnormal	standard conditions	Fig. 4 , Fig. S6 from Liu et al., 2008
primitive erythrocyte differentiation arrested, abnormal	standard conditions	Fig. 2 from Ma et al., 2011
primitive hemopoiesis arrested, abnormal	standard conditions	Fig. 3 from Ma et al., 2011
T cell absent, abnormal	standard conditions	Fig. 4 from Ma et al., 2011
vasculogenesis arrested, abnormal	standard conditions	Fig. 1 from Ma et al., 2011
ventral wall of dorsal aorta lacks all parts of type nucleate erythrocyte, abnormal	standard conditions	Fig. S1 from Ma et al., 2011

CITATIONS (15)