ZFIN ID: ZDB-FISH-150901-1517
Fish name: AB + MO1-smn1
Genotype: AB
Targeting Reagent: MO1-smn1
HUMAN DISEASE MODELED by AB + MO1-smn1
Human Disease Conditions Citations
spinal muscular atrophy standard conditions (2)
GENE EXPRESSION
Gene expression in AB + MO1-smn1
RNA expression
Expressed Gene Structure Conditions Figures
smn1 standard conditions Fig. 1 from Powis et al., 2016
Reporter gene expression No data available
PHENOTYPE
Phenotype in AB + MO1-smn1
Phenotype Conditions Figures
CaP motoneuron morphology, abnormal standard conditions Fig. 4 from McWhorter et al., 2008
CaP motoneuron axon decreased length, abnormal standard conditions Fig. 1 from McWhorter et al., 2003
CaP motoneuron axon increased branchiness, abnormal standard conditions Fig. 1 from McWhorter et al., 2003
cell Cajal body ab1-tmg labeling decreased amount, abnormal standard conditions Fig. 8 from Strzelecka et al., 2010
cell Cajal body decreased amount, abnormal standard conditions Fig. 8 from Strzelecka et al., 2010
cell Cajal body ab1-coil labeling decreased amount, abnormal standard conditions Fig. 8 from Strzelecka et al., 2010
cell small nuclear ribonucleoprotein complex dispersed, abnormal standard conditions Fig. 8 from Strzelecka et al., 2010
lateral line morphology, normal standard conditions Fig. 6 from McWhorter et al., 2003
lateral longitudinal fasciculus morphology, normal standard conditions Fig. 6 from McWhorter et al., 2003
Mauthner neuron morphology, normal standard conditions Fig. 6 from McWhorter et al., 2003
medial longitudinal fasciculus morphology, normal standard conditions Fig. 6 from McWhorter et al., 2003
motor neuron axon branched, abnormal standard conditions Fig. 2 from McWhorter et al., 2003
motor neuron axon increased branchiness, abnormal standard conditions Table S9 from Van Hoecke et al., 2012
motor neuron axon truncated, abnormal standard conditions Fig. S8Table S9 from Van Hoecke et al., 2012
Fig. 2 from McWhorter et al., 2003
motor neuron cell death occurrence, normal standard conditions Fig. 5 from McWhorter et al., 2003
Rohon-Beard neuron morphology, normal standard conditions Fig. 6 from McWhorter et al., 2003
skeletal muscle acetylcholine-gated channel clustering process quality, normal standard conditions Fig. 8 from McWhorter et al., 2003
whole organism smn1 expression decreased amount, abnormal standard conditions Fig. 1 from Powis et al., 2016
whole organism Ab3-ub labeling decreased amount, abnormal standard conditions Fig. 1 from Powis et al., 2016

CITATIONS  (6)