ZFIN ID: ZDB-FISH-150901-12789
Fish name: WT + MO4-tp53
Genotype: WT
Targeting Reagent: MO4-tp53
HUMAN DISEASE MODELED by WT + MO4-tp53
No data available
GENE EXPRESSION
Gene expression in WT + MO4-tp53
RNA expression
Expressed Gene Structure Conditions Figures
alcama standard conditions Fig. 4 with image from Smith et al., 2011
axin2 standard conditions Fig. 9 with image from Mahmoudi et al., 2010
baxa standard conditions Fig. S3 with image from Chakraborty et al., 2009
bbc3 standard conditions Fig. 6 from Rodríguez-Aznar et al., 2011
casp8 standard conditions Fig. 4 with image from Espín et al., 2013
cdkn1a standard conditions Fig. 4 with image from Pei et al., 2019
Fig. 3 with image from Provost et al., 2012
Fig. S3 with image from Chakraborty et al., 2009
col2a1a standard conditions Fig. 4 with image from Moreno-Ayala et al., 2015
Fig. 6 from van Boxtel et al., 2011
crestin standard conditions Fig. 8 with image from Xia et al., 2013
cyp26a1 standard conditions Fig. 7 with image from Feng et al., 2010
cyp26b1 standard conditions Fig. 5 with image from Addison et al., 2018
cyp26c1 standard conditions Fig. 5 with image from Addison et al., 2018
dlx2a standard conditions Fig. 6 from van Boxtel et al., 2011
Fig. 4 with image from Viktorin et al., 2009
dmbx1a standard conditions Fig. 2 from Liu et al., 2008
egr2b standard conditions Fig. 6 with image from Addison et al., 2018
elavl3 standard conditions Fig. 4 with image from Viktorin et al., 2009
elavl4 standard conditions Fig. 4 with image from Viktorin et al., 2009
emx1 standard conditions Fig. 4 with image from Viktorin et al., 2009
emx3 standard conditions Fig. 5 with image from Viktorin et al., 2009
eomesa standard conditions Fig. 3 with image,  Fig. 4 with image from Viktorin et al., 2009
fabp2 standard conditions Fig. 8 with image from Mahmoudi et al., 2010
fezf2 standard conditions Fig. 4 with image from Viktorin et al., 2009
fgf8a standard conditions Fig. 4 with image from Viktorin et al., 2009
foxg1a standard conditions Fig. 4 with image,  Fig. 5 with image from Viktorin et al., 2009
fzd8a standard conditions Fig. 4 with image from Viktorin et al., 2009
gadd45bb standard conditions Fig. 4 from Zhai et al., 2019
gsc standard conditions Fig. 6 from van Boxtel et al., 2011
hand2 standard conditions Fig. 6 from van Boxtel et al., 2011
has2 standard conditions Fig. 4 with image from Smith et al., 2011
hsf1 heat exposure Fig. 5 from Gong et al., 2019
hspa8 heat exposure Fig. 5 from Gong et al., 2019
lhx5 standard conditions Fig. 4 with image from Viktorin et al., 2009
mbpa control Fig. 4 from Mathews et al., 2016
chemical treatment by environment: sirolimus Fig. 4 from Mathews et al., 2016
mdm2 standard conditions Fig. 4 with image from Pei et al., 2019
Fig. S3 with image from Chakraborty et al., 2009
mpx standard conditions Fig. 3 with image from Provost et al., 2012
myb standard conditions Fig. 4 from Cai et al., 2018
myod1 standard conditions Fig. 2 with image from Große et al., 2019
neurod1 standard conditions Fig. 4 with image from Viktorin et al., 2009
neurod6b standard conditions Fig. 4 with image from Viktorin et al., 2009
notch1b standard conditions Fig. 4 from Espanola et al., 2020
otx2b standard conditions Fig. S3 with image from Schaffer et al., 2014
pax2a standard conditions Fig. 2 with image from Große et al., 2019
pax6a standard conditions Fig. 4 with image from Viktorin et al., 2009
Fig. 2 from Liu et al., 2008
plp1a control Fig. 4 from Mathews et al., 2016
chemical treatment by environment: sirolimus Fig. 4 from Mathews et al., 2016
prl standard conditions Fig. 8 from Graf et al., 2015
ptch1 standard conditions Fig. S5 with image from Corallo et al., 2013
rag1 standard conditions Fig. 4 from Cai et al., 2018
reln standard conditions Fig. 4 with image from Viktorin et al., 2009
runx1 standard conditions Fig. 3 from Espanola et al., 2020
shha control Fig. 4 with image from Moreno-Ayala et al., 2015
six3b standard conditions Fig. 2 with image from Große et al., 2019
slc17a6a standard conditions Fig. 4 with image from Viktorin et al., 2009
slc17a6b standard conditions Fig. 4 with image from Viktorin et al., 2009
sox9a standard conditions Fig. 6 from van Boxtel et al., 2011
sox10 standard conditions Fig. 6 from van Boxtel et al., 2011
tbxta control Fig. 4 with image from Moreno-Ayala et al., 2015
tcf4 standard conditions Fig. 4 with image from Viktorin et al., 2009
tp53 chemical treatment: seliciclib Fig. 4 from Lee et al., 2008
standard conditions Fig. 4 with image from Pei et al., 2019
Fig. 3 with image from Provost et al., 2012
Fig. S3 with image from Chakraborty et al., 2009
Fig. 3,  Fig. 4 from Lee et al., 2008
tp63 standard conditions Fig 5 with image from Chen et al., 2019
wnt7ba standard conditions Fig. 4 with image from Viktorin et al., 2009
wnt7bb standard conditions Fig. 4 with image from Viktorin et al., 2009
Reporter gene expression No data available
PHENOTYPE
Phenotype in WT + MO4-tp53
Phenotype Conditions Figures
adenohypophysis has normal numbers of parts of type prolactin secreting cell, normal standard conditions Fig. 8 from Graf et al., 2015
apoptotic process decreased occurrence, abnormal standard conditions Fig. S3 with image from Chakraborty et al., 2009
Fig. S4 from Zeng et al., 2007
apoptotic process disrupted, abnormal radiation Fig. S6 with image from Sidi et al., 2008
apoptotic process occurrence, normal standard conditions Fig. 6 with image from Paridaen et al., 2011
apoptotic process rate, normal x-ray Fig. 1 from Davidson et al., 2008
apoptotic process rate, normal standard conditions Fig. 1 from Davidson et al., 2008
blood cell normal amount, normal standard conditions Fig. 5 with image from Imamura et al., 2008
brain morphology, normal standard conditions Fig. 5 with image from Azuma et al., 2007
caudal vein plexus structure, normal standard conditions Fig. 5 with image from Imamura et al., 2008
cerebellum apoptotic process occurrence, normal control Fig. 6 with image from Hu et al., 2015
ciliary marginal zone apoptotic process occurrence, normal control Fig. 6 with image from Hu et al., 2015
convergent extension involved in axis elongation occurrence, normal standard conditions Fig. 5 from Zoeller et al., 2009
double-strand break repair via homologous recombination increased frequency, abnormal standard conditions Fig. 1 from Gong et al., 2015
double-strand break repair via nonhomologous end joining increased frequency, abnormal standard conditions Fig. 1 from Gong et al., 2015
double-strand break repair via single-strand annealing increased frequency, abnormal standard conditions Fig. 1 from Gong et al., 2015
head morphology, normal standard conditions Fig. 3 from Davidson et al., 2008
intermediate cell mass of mesoderm neutrophil present, normal standard conditions Fig. 3 with image from Provost et al., 2012
intestine well differentiated, abnormal standard conditions Fig. 8 with image from Mahmoudi et al., 2010
nervous system structure, normal standard conditions Fig. 2 with image from Robu et al., 2007
neuron apoptotic process process quality, normal standard conditions Fig. 1 from Ko et al., 2011
neuron differentiation occurrence, normal standard conditions Fig. 2 from Rodríguez-Aznar et al., 2013
notochord morphology, normal standard conditions Fig. S1 with image from Corallo et al., 2013
nucleate erythrocyte immature, abnormal standard conditions Fig. 5 with image from Imamura et al., 2008
optic tectum apoptotic process occurrence, normal control Fig. 6 with image from Hu et al., 2015
renal system process occurrence, normal standard conditions Fig. 5 from Davidson et al., 2008
response to X-ray disrupted, abnormal x-ray Fig. 1 from Davidson et al., 2008
retinal ganglion cell layer maturity, normal standard conditions Fig. 6 with image from Paridaen et al., 2011
serotonin metabolic process process quality, normal standard conditions Fig. 3 from Ren et al., 2013
spinal cord has normal numbers of parts of type neuron, normal standard conditions Fig. 2 from Rodríguez-Aznar et al., 2013
tail bud structure, normal ultraviolet light Fig. 5 with image from Mei et al., 2008
whole organism notch1b expression decreased amount, abnormal standard conditions Fig. 4 from Espanola et al., 2020
whole organism gadd45bb expression decreased amount, abnormal standard conditions Fig. 4 from Zhai et al., 2019
whole organism decreased sensitivity to irradiation, abnormal radiation Fig. S6 with image from Sidi et al., 2008
whole organism mdm2 expression increased amount, abnormal control Fig. 4 with image from Pei et al., 2019
whole organism hsf1 expression increased amount, abnormal heat exposure Fig. 5 from Gong et al., 2019
whole organism tp53 expression increased amount, abnormal control Fig. 4 with image from Pei et al., 2019
whole organism hspa8 expression increased amount, abnormal heat exposure Fig. 5 from Gong et al., 2019
whole organism cdkn1a expression increased amount, abnormal control Fig. 4 with image from Pei et al., 2019
whole organism morphology, normal standard conditions Fig. 3 with image from Luo et al., 2013
Fig. 7 from Yue et al., 2013
Fig. 3 with image from Provost et al., 2012
Fig. S6 from Chopra et al., 2010
Fig. 2 from Wood et al., 2009
Fig. 5 from Zoeller et al., 2009
Fig. 3 with image from Mei et al., 2008
Fig. S2 from Zoeller et al., 2008
Fig. 1 with image from Robu et al., 2007
whole organism semi-viable, abnormal x-ray Fig. 1 from Davidson et al., 2008
whole organism viable, normal standard conditions Fig. 1 from Davidson et al., 2008

CITATIONS  (49)

Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.