CRISPR

CRISPR8-fbn1

ID

ZDB-CRISPR-250714-52

Name

CRISPR8-fbn1

Previous Names

None

Target

fbn1 (1)

Sequence

5' - GGGTATCTGTGCTCCTGTCCACGCGG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf4315	fbn1

Expression

Gene expression in Wild Types + CRISPR8-fbn1

No data available

Phenotype

Phenotype resulting from CRISPR8-fbn1

No data available

Phenotype of all Fish created by or utilizing CRISPR8-fbn1

Phenotype	Fish	Conditions	Figures
whole organism wnt11 expression decreased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
whole organism irx5a expression decreased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
whole organism lepa expression increased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
pericardium edematous, abnormal	fbn1^zf4315/+	standard conditions	Fig. 4 from Huang et al., 2025
whole organism ctnnb1 expression decreased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
whole organism lepb expression increased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
Meckel's cartilage increased distance ceratohyal cartilage, abnormal	fbn1^zf4315/+	standard conditions	Fig. 4 from Huang et al., 2025
post-vent region curved, abnormal	fbn1^zf4315/+	standard conditions	Fig. 4 from Huang et al., 2025
whole organism fosl2 expression increased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
Meckel's cartilage increased size, abnormal	fbn1^zf4315/+	standard conditions	Fig. 4 from Huang et al., 2025
whole organism tgfb1a expression increased amount, abnormal	fbn1^zf4315/+	standard conditions	Fig. 6 from Huang et al., 2025
mouth protruding, abnormal	fbn1^zf4315/+	standard conditions	Fig. 4 from Huang et al., 2025
heart contraction decreased process quality, abnormal	fbn1^zf4315/+; f1Tg	standard conditions	Fig. 4 from Huang et al., 2025
angiogenesis decreased process quality, abnormal	fbn1^zf4315/+; s843Tg	standard conditions	Fig. 4 from Huang et al., 2025
blood vessel solid configuration, abnormal	fbn1^zf4315/+; s843Tg	standard conditions	Fig. 4 from Huang et al., 2025
intersegmental vessel disorganized, abnormal	fbn1^zf4315/+; s843Tg	standard conditions	Fig. 4 from Huang et al., 2025
dorsal aorta increased diameter, abnormal	fbn1^zf4315/+; s843Tg	standard conditions	Fig. 4 from Huang et al., 2025
blood vasculature EGFP expression spatial pattern, abnormal	fbn1^zf4315/+; s843Tg	standard conditions	Fig. 4 from Huang et al., 2025

Citations