CRISPR

CRISPR1-tgfb1b

ID

ZDB-CRISPR-180613-3

Name

CRISPR1-tgfb1b

Previous Names

None

Target

tgfb1b (1)

Sequence

5' - GGAACCAGAAGTAGAAGAGAAGGA - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
zf2126	tgfb1b

Expression

Gene expression in Wild Types + CRISPR1-tgfb1b

No data available

Phenotype

Phenotype resulting from CRISPR1-tgfb1b

No data available

Phenotype of all Fish created by or utilizing CRISPR1-tgfb1b

Phenotype	Fish	Conditions	Figures
whole organism foxo3a expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism gpx4b expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism gpx1a expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism gpx4a expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
ventral wall of dorsal aorta myb expression decreased distribution, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 1 from Zhang et al., 2017
erythrocyte differentiation decreased occurrence, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 2 from Zhang et al., 2017
whole organism nox1 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism foxo4 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
ventral wall of dorsal aorta tal1 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 4, Fig. 6 from Zhang et al., 2017
whole organism gpx7 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism ddit3 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
ventral wall of dorsal aorta jun expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 4 from Zhang et al., 2017
whole organism foxo1a expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
ventral wall of dorsal aorta runx1 expression amount, ameliorated	tgfb1b^{zf2126/zf2126}	chemical treatment: glucose	Fig. 6 from Zhang et al., 2017
whole organism eif2ak3 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism hsp90b1 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
JNK cascade decreased occurrence, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 4 from Zhang et al., 2017
whole organism akt2 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism foxo3b expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism gpx1b expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism ern1 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
definitive hemopoiesis decreased occurrence, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 1 from Zhang et al., 2017
whole organism ccnd2a expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism pck2 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism gadd45aa expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism bcl2l11 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism me1 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
ventral wall of dorsal aorta g6pc3 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism gpx3 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
ventral wall of dorsal aorta tal1 expression decreased distribution, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 2 from Zhang et al., 2017
whole organism g6pc3 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
whole organism idh2 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
myeloid cell differentiation decreased occurrence, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 2 from Zhang et al., 2017
ventral wall of dorsal aorta runx1 expression decreased distribution, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 1, Fig. 2, Fig. 4 from Zhang et al., 2017
hematopoietic stem cell decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 1 from Zhang et al., 2017
blood glucose decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
whole organism foxo1b expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 5 from Zhang et al., 2017
ventral wall of dorsal aorta runx1 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 4, Fig. 6 from Zhang et al., 2017
lymphoid progenitor cell differentiation decreased occurrence, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 2 from Zhang et al., 2017
whole organism atf6 expression increased amount, abnormal	tgfb1b^{zf2126/zf2126}	standard conditions	Fig. 6 from Zhang et al., 2017
endothelial cell g6pc3 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; s843Tg	standard conditions	Fig. 5 from Zhang et al., 2017
endothelial cell map3k7 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; y1Tg	standard conditions	Fig. 4 from Zhang et al., 2017
endothelial cell mapk9 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; y1Tg	standard conditions	Fig. 4 from Zhang et al., 2017
endothelial cell jun expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; y1Tg	standard conditions	Fig. 4 from Zhang et al., 2017
endothelial cell mapk10 expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; y1Tg	standard conditions	Fig. 4 from Zhang et al., 2017
endothelial cell mapk8a expression decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; y1Tg	standard conditions	Fig. 4 from Zhang et al., 2017
ventral wall of dorsal aorta hematopoietic stem cell decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; zf169Tg; zf2072Tg	standard conditions	Fig. 2 from Zhang et al., 2017
caudal hematopoietic tissue hematopoietic stem cell decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; zf2072Tg; zf2128Tg	standard conditions	Fig. 2 from Zhang et al., 2017
hematopoietic stem cell decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; zf2072Tg; zf2128Tg	standard conditions	Fig. 4 from Zhang et al., 2017
hematopoietic stem cell amount, ameliorated	tgfb1b^{zf2126/zf2126}; zf2128Tg	chemical treatment: glucose	Fig. 6 from Zhang et al., 2017
definitive hemopoiesis decreased occurrence, abnormal	tgfb1b^{zf2126/zf2126}; zf2128Tg	standard conditions	Fig. 1 from Zhang et al., 2017
caudal hematopoietic tissue GFP expression decreased distribution, abnormal	tgfb1b^{zf2126/zf2126}; zf2128Tg	standard conditions	Fig. 1 from Zhang et al., 2017
hematopoietic stem cell decreased amount, abnormal	tgfb1b^{zf2126/zf2126}; zf2128Tg	control	Fig. 1, Fig. 6 from Zhang et al., 2017

Citations