Genomic Feature
b337
- ID
- ZDB-ALT-970731-16
- Name
- b337
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Kimmel Lab
- Current Source
-
Zebrafish International Resource Center (ZIRC)
(
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European Zebrafish Resource Center (EZRC) ( order this ) - Other Pages
Notes
| Comment | Citation |
|---|---|
| Null allele (nonsense mutation in ORF). | ZFIN Staff |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 3408277 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
-
Null allele (nonsense mutation in ORF).
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T at position 391 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Gln>Stop (1)
- Flanking Sequence
-
CAGGTGCTTCTGCTGCACGCGCTTGAAGCGGCATGACTGCGCGTAGCCCCGGTTCTTCAGGGTCCGGCGCTTCTGCTTCAGGCGGATCACCTCGTCCTTGGTGAAGCCCCGCAGGTGTCGGTTGAGCTCCCGTACGGACATGGTCACAAGCTGGTCGTCGGAGAAGCGGTCCTCCACGTTCAGGCCGCCCCCCACGCCGTGGTGACCCTGCTGACCCGGGTGGCCGTGCGGGTGGTGATGGTGGTGGTGGCGGTGGTGGAGCTGCTCGGGCGAGGTAGGAGAAGGGCTGTCGGGATCCTGGCTGTGGTGGTGGTGGTGGTGATGGTGGGGGTGGTGGCCGTGAGCGCCGGGGTGACCCGACAGGTCGTCGGGGTGATGGGGGATCGCGCCGTACTGGTGTTGATGGTGATGGTGCTGCGGCTGCTGCTGCTGCTGTTGCTGCGCGTGGCCGTGGTGGTGATGCGCGCCCCTGTATCCATCAAACGCTCCAGCTTGCAGCT
G/A CTGCTGCACGTGAGGGGGCGGCGGGTGCCCGTGGGCCGTGGCACCGATCAGAGCCTCCACCGCGTCTTCGGGCGTGAGGCTTAACGTCTGCGGGTCGATCTGCTGCGGGTACGCGCCGCTGGGCATCCAGTACAGCTCCTCCAGGTGGTTCTTCTGTTCTGTGGGGCTGAAGCTCGGGGAGGACGGCACGGAGCTGCACGGGGTGCTGATAGGAGTGGAGGACACGGAGCCCTGCGGCTGGAGGCGGTTGCACTGCCGTATATTGGCGCGGTCGTGCGCCGCCATGGCCTCTTTCTTTACCTCGAATTTCATTAAATCAAAGTCATTGACATATTCCAACGCCAGCGGGCTGGTGGGCAGCTCGGGCCCCATGGCGAGATCGGCGCTCATCGTGCCCCTGTTCTTCAGCAAAGTGTTGGGAAAACCAGACTTTGGCGTTTTTTCTCCCCTCTCTTTGCGCATGCAATGTTCTTGATGGGTCTCCGACCGCGGCGCGCTCG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mafbab337/b337 | Homozygous | ♀+/- ♂+/- | 6 figures  from 4 publications | 5 figures from 4 publications | |
| mafbab337/b337 (AB) | Homozygous | Unknown | 7 figures from 5 publications | 10 figures from 6 publications | |
| mafbab337/+ | Heterozygous | ♀+/- ♂+/- | Fig. 2 from Tran et al., 2017 | ||
| mafbab337/+ (AB) | Heterozygous | Unknown | |||
| mafbab337/b337; nkhspGFFDMC28CEt; nkuasgfp1aTg | Complex | Fig. 8 from Itoh et al., 2020 | |||
| mafbab337/b337; s1020tEt; s1999tTg | Complex | Fig. 4 from Ma et al., 2014 | Fig. 4 from Ma et al., 2014 |
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Supplemental Information
- Genotyping protocol
- b337.pdf
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Itoh, T., Takeuchi, M., Sakagami, M., Asakawa, K., Sumiyama, K., Kawakami, K., Shimizu, T., Hibi, M. (2020) Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development (Cambridge, England). 147(19):
- Ghosh, P., Maurer, J.M., Sagerström, C.G. (2018) Analysis of novel caudal hindbrain genes reveals different regulatory logic for gene expression in rhombomere 4 versus 5/6 in embryonic zebrafish. Neural Development. 13:13
- Tran, M.T.N., Hamada, M., Jeon, H., Shiraishi, R., Asano, K., Hattori, M., Nakamura, M., Imamura, Y., Tsunakawa, Y., Fujii, R., Usui, T., Kulathunga, K., Andrea, C.S., Koshida, R., Kamei, R., Matsunaga, Y., Kobayashi, M., Oishi, H., Kudo, T., Takahashi, S. (2017) MafB is a critical regulator of complement component C1q. Nature communications. 8:1700
- Ma, L.H., Grove, C.L., Baker, R. (2014) Development of oculomotor circuitry independent of hox3 genes. Nature communications. 5:4221
- Zannino, D.A., Sagerström, C.C., and Appel, B. (2012) Olig2-expressing hindbrain cells are required for migrating facial motor neurons. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(2):315-326
- Choe, S.K., Zhang, X., Hirsch, N., Straubhaar, J., and Sagerström, C.G. (2011) A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Developmental Biology. 358(2):356-67
- Radosevic, M., Robert-Moreno, A., Coolen, M., Bally-Cuif, L., and Alsina, B. (2011) Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear. Development (Cambridge, England). 138(3):397-408
- Bingham, S.M., Sittaramane, V., Mapp, O., Patil, S., Prince, V.E., and Chandrasekhar, A. (2010) Multiple mechanisms mediate motor neuron migration in the zebrafish hindbrain. Developmental Neurobiology. 70(2):87-99
- Stedman, A., Lecaudey, V., Havis, E., Anselme, I., Wassef, M., Gilardi-Hebenstreit, P., and Schneider-Maunoury, S. (2009) A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3. Developmental Biology. 327(2):566-577
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