Genomic Feature
zf3301
- ID
- ZDB-ALT-211102-19
- Name
- zf3301
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 12: 28801321 - 28801346 (GRCz11) (1) Details
- Nucleotide change
- AGTGCCCTGAAGTGGGAGAAGCCAAT/TGCAA
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 5 bp inserted / 26 bp deleted in Exon 2 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
CGCGAACACAGGGAGAACATGCAAACTCCACACAGAAACGCTAACTGAGCCGAGGTTCAACCCAGCGACCTTCTTGCTGTGAGGCGACAGCACTACCTACTGCGCCACTGCGTTGCCCGAAAGAACCCCTTCATAGATCTAATTCACTATTAAAGTCCACACACAAATGAAGTATACATTATGACCACCTGTCTAATATGCAGGTAATCCTCCCTGTGCTCCCAAAAGAGCTAACCTACCAAAGCATGAACTCTGCAAGACCCCAGTAGGTGTCCTGTGTTATCTGGCACTGACACATTCCCATGAGATCTTTCTAGTCTTGTAGGTTGTGAGGTGTTAGAAGATGCTTTGGCTTATCAACTGATTCTTATATATGTTTTTGTGTGACAGCAAAATATTATAAATATTCATCAATTTCATCCTACAGTGTTTTGAGGAGAATCAACTTGCATCTTTAGATCCTATTAAGCAATTCGGCAGCTGGTTTGATCAGGCCACCA
AGTGCCCTGAAGTGGGAGAAGCCAAT/TGCAA GCAATGTGTCTTGCAACAGCGACTAAGTAGGTATCTCAATTTGTTCATCAATGCCTGCAATGACACAAGTTAGCTTAAAAAGGGATAATTCACCCCCCAAAAAAAATTTATTAAAAGTAATTTATTGTTGTTTTATTAATTTCTTTCTTCTGTCAAACTCAAAACAAGATGATCTGAAGAATTTTGGAAACAAGCAGCTCTTGACATCCATAGTAGGAAGAAAAAATAATATCAATGTCAATAAAAATTCTTCCTAAATTTTTTGTGTGTGTGTGTTCAACAGAAGAAAGTAGCACGAACAGGTTTGCAACAAGTACAAATCAGAAGTTTGATTTGTGGGTTAACTATCCCTTAACATGTCATGTAGTCTTTTGGCAGTGTATTATTAATGGAATAACTTTGATTTATTAAGCTTACTAATTCAATGTTGCCTTAATTGATTCGTCTTGTCTCTTCTGAAGGGACGGTCACCCCTCTGCACGCATGGTCCTTCTAAAAGG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pnpozf3301/zf3301 (TL) | Homozygous | ♀+/- ♂+/- | 4 figures from Ciapaite et al., 2019 |
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Supplemental Information
- Genotyping protocol
- None
- Delgadillo-Silva, L.F., Tasöz, E., Singh, S.P., Chawla, P., Georgiadou, E., Gompf, A., Rutter, G.A., Ninov, N. (2024) Optogenetic β cell interrogation in vivo reveals a functional hierarchy directing the Ca2+ response to glucose supported by vitamin B6. Science advances. 10:eado4513
- Ciapaite, J., Albersen, M., Savelberg, S.M.C., Bosma, M., Tessadori, F., Gerrits, J., Lansu, N., Zwakenberg, S., Bakkers, J.P.W., Zwartkruis, F.J.T., van Haaften, G., Jans, J.J., Verhoeven-Duif, N.M. (2019) Pyridox(am)ine 5'-phosphate oxidase (PNPO) deficiency in zebrafish results in fatal seizures and metabolic aberrations. Biochimica et biophysica acta. Molecular basis of disease. 1866(3):165607
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