Genomic Feature
rmc200
- ID
- ZDB-ALT-210716-8
- Name
- rmc200
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Functional genomics and therapeutics / ENT
- Current Source
- Other Pages
-
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 22: 11451 - 11464 (GRCz11) (1) Details
- Nucleotide change
- CGTCACGGTGAGT/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 13 bp deleted in Exon 1 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TATTATTGACTTTCTACCCCCTTGGCATTTTTGTTTACTGTATTGTCATGTATCTGTTGTTTAAAGCATAATAAAAATGATGATGATTTGCCATGCAGATGAAAACATTATATTTGGGCTTTTAAACTCCACAGAGGAACATGACGGTTTCCTGTAATAAACTGTATCATGTTTCTGAAGATTTGTCACGCATGTTGTTGGAAACAAACACAGCGCTTATTATTATGATTATTATTATCATTAGTAGTAAACGAATGACAGAAATGCCGACATTTATATTATTATAAGATAAAATATGCGCTTATATAGCGCAGGATCACTCGTGGGCTGTGTTTAAAAGCGTAGTGAGCGCCCTCTGCAGTGCGCAGTCTCTGTGGGCGGCGGAGTGCGTGATTTGAGGCGCATGCGCAGTGAGTGTTGGAGCAGAGAGTCAGACTGATCAACATGGCGGCTGTGTGTTTCTCCTTGAGCCGCTGCTGCTCTGCTGTTCACCGGCCCGC
CGTCACGGTGAGT/- CCACACCTGATCTGCACTGATAATCGATCACCACCGCTCATCAATAACCCGTCTGATACCGATCATGACACGTGACTGACACACAGAAGCCGAAGTCCAGCTCTACGAGTACTGTCGTCAAACTCACCGGCGCGGATGAGCGGAAATATCGGAGAATAATGCGGTGTATGAGTGTGTTTATAGTGAAGTGCTGCGCCATTATGATGGAGGAATGACAGTATCTGCTTTATATAACGCTGACTGAGCGCGTGTGTGTGTGTGTGTCATCATGTATATNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNCTGCAGTGCTGCTGCTGTTTATAATGTGAAGGTGTACAGTGTCCAGAGCTGATCTGATGCTGATCTGAGTGTTCTGACAGAGTGTGTGTGCGGTTTTGAGTGTTTTGAGTGTGTGTTTGGTAAC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sdhbrmc200/rmc200 (AB) | Homozygous | ♀+/- ♂+/- | 9 figures  from 2 publications | ||
| sdhbrmc200/+ (AB) | Heterozygous | Unknown | 6 figures from 3 publications |
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Supplemental Information
- Genotyping protocol
- None
- Miltenburg, J.B., Gorissen, M., van Outersterp, I., Versteeg, I., Nowak, A., Rodenburg, R.J., van Herwaarden, A.E., Olthaar, A.J., Kusters, B., Conrad, C., Timmers, H.J.L.M., Dona, M. (2024) Characterisation of an Adult Zebrafish Model for SDHB-Associated Phaeochromocytomas and Paragangliomas. International Journal of Molecular Sciences. 25(13):
- Dona, M., Lamers, M., Rohde, S., Gorissen, M., Timmers, H.J.L.M. (2021) Targeting the Redox Balance Pathway Using Ascorbic Acid in sdhb Zebrafish Mutant Larvae. Cancers. 13(20):
- Dona, M., Waaijers, S., Richter, S., Eisenhofer, G., Korving, J., Kamel, S.M., Bakkers, J., Rapizzi, E., Rodenburg, R.J., Zethof, J., Gorissen, M., Flik, G., Deen, P.M.T., Timmers, H.J. (2020) Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics. Endocrine-related cancer. 28(1):65-77
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