Genomic Feature
n3
- ID
- ZDB-ALT-210106-4
- Name
- n3
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Chaudhry Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 12: 2514431 - 2514434 (GRCz11) (1) Details
- Nucleotide change
- TTCG/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
TAATTTCAAAAAATAAGTAAATATAATGCATTAAAATAAATAAATAAATAAAATGCAATAAATATAAAAAATGCAACAATTAAATAATAAATTGTACATATGCAATAAATAAATAAATAGCAATAAAAAATGCAATAAATAAATAAATTAAAATAAAAAACTAAAATTTAAAGCGACAAAAAAATTACTAAAAATCTATTACTTGGACAAAAATTTGTTTAAATTCCCTGACTTACAATGTTTGAAAGTCATCAAGTTTCCATATATTCCTTGACCTGTGGGAACCCTGGTTAAAACCCTGCAGCCGTTTGGTGAGATCTGTTTTCAGTTTTCAGCTGAATGGTGTGAAGGTGCTCGTGTGCGAATCTTGACATGCTGCAAAGCAGGGGCGTCAGGTTGGCACTCACCGTTAGCTTGATAACCCATGCCCAGGATGACCTCTGGGGCCCGATAATAGCGTGTCACGACATAAGGAGTCATGAGGAGGCCGGTTGCAGCCG
TTCG/- GGCCAGACCGAAATCCAGGATCTTCAGCGTGCAGTCCGATTTCACTACTATATTACTGGGTTTCAGATCCTAGGAAAAGATGAATAGTTCAGCAAAGGTAAGATGTAGGACTCTGAAAATATGTAGGACTCCTTTTATGTGATATGCATATATGCACTACCTGACAAAAGTCTTGTCACTTATCCAAGTTTTAGGAAAAACCAATAATAACTTGACTTCTGAACTGCATCCCAATCATCACAAAAACTGCAGAAGACCTACTGGAACCAGCATGGAGCGGAGATTCTCACAGAAATCAGTCAAGTTTGGTAAAGGAAAAATCATGGTTTGGGGTTACAGTCAATAAGCGTAATCTTAACGCGTTTGCCTTTCATAGAAGCCACTTCTGATACCAAACGATCAACTAGAAGTCAAGTTAATATTTGTTTTCCCTAAAACTTGGATAAGTGACAAGACTTTTGTCAGGTAGTGCTCTTACAACCGGAATCAACAACAAGCCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mapk8bn3/n3 | Homozygous | ♀-/- | 3 figures  from Derrick et al., 2022 | 2 figures from Derrick et al., 2022 | |
| mapk8bn3/n3 (AB) | Homozygous | ♀-/- ♂-/- | 3 figures from Santos-Ledo et al., 2020 | ||
| mapk8bn3/n3; twu34Tg (AB) | Complex | Fig 5 from Santos-Ledo et al., 2020 | |||
| mapk8an2/n2; mapk8bn3/n3 | Complex | 4 figures from Derrick et al., 2022 | 2 figures from Derrick et al., 2022 | ||
| mapk8an2/n2; mapk8bn3/n3 (AB) | Complex | 3 figures from Santos-Ledo et al., 2020 | Fig 7 from Santos-Ledo et al., 2020 | ||
| mapk8an2/n2; mapk8bn3/n3; twu34Tg (AB) | Complex | 2 figures from Santos-Ledo et al., 2020 | |||
| mapk8an2/n2; mapk8bn3/n3; mapk9n4/n4 | Complex | 2 figures from Derrick et al., 2022 | 2 figures from Derrick et al., 2022 |
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Supplemental Information
- Genotyping protocol
- None
- Derrick, C.J., Santos-Ledo, A., Eley, L., Henderson, D.J., Chaudhry, B. (2022) Sequential action of jnk genes establishes the embryonic left-right axis. Development (Cambridge, England). 149(9):
- Santos-Ledo, A., Washer, S., Dhanaseelan, T., Eley, L., Alqatani, A., Chrystal, P.W., Papoutsi, T., Henderson, D.J., Chaudhry, B. (2020) Alternative splicing of jnk1a in zebrafish determines first heart field ventricular cardiomyocyte numbers through modulation of hand2 expression. PLoS Genetics. 16:e1008782
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