Genomic Feature
mk28
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 13: 15194415 - 15194418 (GRCz11) (1) Details
- Nucleotide change
- AGCA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp deleted in Exon 3 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- at position 202 (1)
- Flanking Sequence
-
GACTGTAGAGTTGAATTTTCAACATCAAAAGTTAACAGAGCAGAGATTAAGGTTCCTTGACAATTCACTACTGTAAAAACAAGGAAAAAACTAAATTAGGAAACGTTAATTAACAGATGTTTTTTACAGTGCAGACTTCAAAGCAAATTATGAAAAAGAAGGCCATTTTATGACTTTTCCCTTTATTTTTTGTCTATAGGTGGACCCAAACCTACAGATACTCTAGCTCCTTCTTTAACTGGAGCCACAGCAACCGTTACAACGGCAACAGTTCACACTGTCCCACCTACTACTCTTCCTCTGCTAATGCCACCTGCAGGAGATGCCCCAGTACATTCAACTGCCCCTTGCAAACAAGCAACACAGGAACCGTCTCCTGATTCTGTTCTTCAAGTTGCAGAGACACAGCAGGTGGAGCAAGTTTCTCCTCCAGCTCCGGCACCTACACCTGAACCAGTTCCCCAAACTGAAATCACACCACAAGTTATAGCACCTTCCCA
AGCA/- GCTCCTGACATGTCCTCACCAATTAATTTAAAAGTCTTAACACACACTGGAGAAGCTGTTACCATAACACCTGTTTCTAGAGCACTAGATAGCCTTGGCTTTACAATCACCTCATCTGCTGGTGAATCTCCCATCTCCACCTCATGTACTCAAGCGTCCATCTCAAACACTTCTCAAATCCAATTGACAAGGCCTTGCTCGACCACCCAGAGCTCAGGGAATATACAGGTGCCAAAAAAAGAAGTCAAAGACTTGGACACTTCTGAGAAGTTCCCGGTCCAAGACACTAATCTCCCATTGCGACAGGAAAGAACATTTCAGGGGCCTGAAGAGACTTCCGACCCAATTGCAAATGAGGTAATAATCAACTCAAAGCACTTCACTGTTTTTCTGTGAAAAAATTGGGACAGAAGGGGTTGTCACATCAAAGATATTTAATGTAATTCCTGTAAGTATTGTCAAAAATAAGCATGTACCACAGGAACAGGGAATGGATTTAG - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| mavsmk28/mk28; zbtb24mk22/mk22 | Complex | Fig. 4 from Rajshekar et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Lefkopoulos, S., Polyzou, A., Derecka, M., Bergo, V., Clapes, T., Cauchy, P., Jerez-Longres, C., Onishi-Seebacher, M., Yin, N., Martagon-Calderón, N.A., Potts, K.S., Klaeylé, L., Liu, F., Bowman, T.V., Jenuwein, T., Mione, M.C., Trompouki, E. (2020) Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 53:934-951.e9
- Rajshekar, S., Yao, J., Arnold, P.K., Payne, S.G., Zhang, Y., Bowman, T.V., Schmitz, R.J., Edwards, J.R., Goll, M. (2018) Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. eLIFE. 7:
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