Genomic Feature
ig4
- ID
- ZDB-ALT-161103-5
- Name
- ig4
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one delins (1)
- Protocol
- embryos treated with
- Lab of Origin
- Vermot Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Delins
- Variant Location
- Chr 22: 15898587 - 15898596 (GRCz11) (1) Details
- Nucleotide change
- CAGAAGGAA/GATGCTGGGAGAG
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 13 bp inserted / 9 bp deleted in Exon 1 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
TTTTTTTTTGCAAAGACAAGAGAGGGAGAGAGAATCAGAGAGGGAGAGGGAGATAGAGAGAGAGAGGAGGGATTTCTCTCGCATCATGTTGTACTCGTTTAACTCGTTTTACCGAGGGGGCGTGGAGTGACTCGGTGATTTAAAGAAGAGCCCGTGCGCTCTCAACATCCAAGACGAAAGGCGCACACGCCGGAGAGCAGCAGCTATATACCGGGGCTAAAATTAGGGACGGATAGTGCGTATTTCCTCCGCTTCTTATAATTGGTCCAGCTTGCGCTGCCGTGATATTTATAAGATAAAGGTCTTCCACCACTCATACTTTCTGCATGAGTGTTAAACATAGTGTAAAGAGCAGAGCAGAGTTGTAGTGCACTACAACCAAAGTTTCTCCGAGGGATTGCAACAAATCCCCGATCTTTAAAGTTTGTTTTACCTTAACTGGGACGACTGGAAATGGCTTTGAGTGGAACGATTTTACCGTCTATTTCCACATTTTCGGC
CAGAAGGAA/GATGCTGGGAGAG AAATGCTGGGAGAACGTGAGTATTGTTTTCTATTTATTTATTTTCACGTCATTGTTATGTCTAAGTGGTTTCATGCTATATTAAATCTGCTTTTGTTCATATTTACGCTGTAATTTCTACAAACGTTTTTCTTTTTTAAAACAAGTTAGCTAACTTGAATAAAGTTAGCCAGCGTGAGGAATGTTTGTTTATGTTTTTAACTAAATAGCGAGTTTGTAACTATAGCAACAGCCACTCGATCGATAAACCAATACTTTTTTCAATCTATATTCTATTAACACATTACAATATAAGCTAAAACAGTGTTTTATTTCGAATAGTAGCCTATTTGTGTACTGCAAACACATTTATAAAGCATACTATTAACTTTTTTGTGCTCTTAAAATGTTTAAAATCAAAACTAATCGAAATCAACCTGTTTCATTGCAGAGGTGGAAGGATGAACTGGACAGGTCCATGCATCTCAGCTGCATAGCTGACCTATCTAACATGGACAACCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| klf2aig4/ig4 | Homozygous | ♀+/- ♂+/- | Fig. 7  from Goddard et al., 2017 | ||
| klf2aig4/ig4 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 6 from Steed et al., 2016 | Fig. 7 from Steed et al., 2016 | |
| klf2aig4/ig4; mw43Tg; s957Tg | Complex | Figure 5 from Gálvez-Santisteban et al., 2019 | |||
| klf2aig4/ig4; rk8Tg; ubs3Tg | Complex | 2 figures from 2 publications | 2 figures from 2 publications | ||
| klf2aig4/ig4; s957Tg | Complex | Figure 5 from Gálvez-Santisteban et al., 2019 | Figure 5 from Gálvez-Santisteban et al., 2019 | ||
| klf2aig4/ig4; ubs10Tg | Complex | Fig. 7 from Steed et al., 2016 | |||
| klf2aig4/ig4; um14Tg | Complex | Figure 7 from Duchemin et al., 2019 | Figure 7 from Duchemin et al., 2019 | ||
| klf2aig4/ig4; y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 | Complex | Figure 7 from Li et al., 2021 |
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Supplemental Information
- Genotyping protocol
- None
- Chow, R.W., Fukui, H., Chan, W.X., Tan, K.S.J., Roth, S., Duchemin, A.L., Messaddeq, N., Nakajima, H., Liu, F., Faggianelli-Conrozier, N., Klymchenko, A.S., Choon Hwai, Y., Mochizuki, N., Vermot, J. (2022) Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling. PLoS Biology. 20:e3001505
- Vignes, H., Vagena-Pantoula, C., Prakash, M., Fukui, H., Norden, C., Mochizuki, N., Jug, F., Vermot, J. (2022) Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis. Developmental Cell. 57(5):598-609.e5
- Li, W., Tran, V., Shaked, I., Xue, B., Moore, T., Lightle, R., Kleinfeld, D., Awad, I.A., Ginsberg, M.H. (2021) Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. eLIFE. 10:
- Duchemin, A.L., Vignes, H., Vermot, J. (2019) Mechanically activated Piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis. eLIFE. 8:
- Gálvez-Santisteban, M., Chen, D., Zhang, R., Serrano, R., Nguyen, C., Zhao, L., Nerb, L., Masutani, E.M., Vermot, J., Burns, C.G., Burns, C.E., Del Álamo, J.C., Chi, N.C. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLIFE. 8:
- Goddard, L.M., Duchemin, A.L., Ramalingan, H., Wu, B., Chen, M., Bamezai, S., Yang, J., Li, L., Morley, M.P., Wang, T., Scherrer-Crosbie, M., Frank, D.B., Engleka, K.A., Jameson, S.C., Morrisey, E.E., Carroll, T.J., Zhou, B., Vermot, J., Kahn, M.L. (2017) Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis. Developmental Cell. 43(3):274-289.e5
- Steed, E., Faggianelli, N., Roth, S., Ramspacher, C., Concordet, J.P., Vermot, J. (2016) klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis. Nature communications. 7:11646
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