Genomic Feature
ct806
- ID
- ZDB-ALT-131122-7
- Name
- ct806
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one insertion (1)
- Protocol
- embryos treated with zinc finger nuclease
- Lab of Origin
- Prober Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Insertion
- Variant Location
- Chr 10: 10599731 - 10599732 (GRCz11) (1) Details
- Nucleotide change
- -/ACGA
- Variant Notes
-
4bp insertion
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 4 bp inserted in Exon 3 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation (1)
- Flanking Sequence
-
TCTGTTCTTCTCTGGTGGAATGAGCTGCCAACCTCCATGTAAAACCCTGAAACCATCACATCTAAAGAAGCGGCTGAAGGCCTCTTCCACAAGCACTTTACCACCAACGCACACATACTCAGTCTAATTATATTCAGATTCAGTTTCCATAACCCCACACTTACATTAGCGTTTTACTGAAGAGCATTATAATTGGTCAAAGTACCTCACATGCTTCAATTATATAGGTACAACATTCTGAAAGTTCACATAGAAAGGTTATTTGTAATGTGCGAGTGGCTCTCAAGTTACCATGACAATGTGGTTCTTGGGCAGATTTGGCGGGAGCTGATAGATATGGCACCAGTAAGTAGTCTCTTGTGTGGGGATGATGACATCAGGGGCCAGGACCTCCAGGGTGCGTACATCTTTCGGGAGATGGGGGGACGGGGTGTCTGGACGCAGGAGCAGGACTCGCTGGACGCCAGGCTGGAGACGGGATATATTGAGCTCATGCAACGA
-/ACGA TAGGATGGGATGCTCCAGCATGGTGTAGATTATGTGGACAGTGCCTTCCTGGAAAGATTTTATTATTATCTTTAGGTAAACAGTTGAGTTTTACCATTGTATAATCCAATCAACCTACCTGCAAGTCTGGTGAGAGCACCTTTAACTTAGCTTAGCATAAATCATTGAATAGGATTAGACCATTAGCATCTTGCTCAAACATTTCTCAAATAATTTAAATAATCAGATATTTTTCCCATTTAAAGCTTGACTGATCAGCCTAGAAATAGCAATGTTTAATGCCCAATCAGTCTTAGAACACAATGTATCTACAGAATAGTCAAGCTTTAAATAGGAAAACTATGGAAATCATTTATACATTTTGAGCGAGATGCTAATGGTCTAATCCAATTTAACTCTTGAGGACTTGTGCAATGAGGTTATTTCCAAAAAGTGTTGAGCGTTATTTGGGATACTTAAAGTTATTTTTTATTCTGGGATACAAGGAGGCAGTTAGAAATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| dbhct806/ct806 | Homozygous | ♀+/- ♂+/- | 2 figures from Singh et al., 2015 | ||
| dbhct806/ct806 (AB/TL) | Homozygous | ♀+/- ♂+/- | Fig. 6  from Singh et al., 2017 | ||
| dbhct806/+ (AB/TL) | Heterozygous | ♀+/- ♂+/- | Fig. 6 from Singh et al., 2017 | ||
| dbhct806/ct806; ct831Tg | Complex | Fig. 8 from Singh et al., 2015 | |||
| dbhct806/ct806; ct853Tg (AB/TL) | Complex | Fig. 6 from Singh et al., 2017 | |||
| dbhct806/ct806; pku2Et | Complex | Fig. S7 from Chen et al., 2017 | |||
| dbhct806/ct806; zf12Tg | Complex | Fig. 4 from Singh et al., 2015 | |||
| dbhct806/+; ct853Tg (AB/TL) | Complex | Fig. 6 from Singh et al., 2017 | |||
| dbhct806/+; zf12Tg | Complex | Fig. 4 from Singh et al., 2015 |
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Supplemental Information
- Genotyping protocol
- None
- Kim, J., Hyun, M., Hibi, M., You, Y.J. (2021) Maintenance of quiescent oocytes by noradrenergic signals. Nature communications. 12:6925
- Chen, S., Reichert, S., Singh, C., Oikonomou, G., Rihel, J., Prober, D.A. (2017) Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 95(1):153-168.e6
- Singh, C., Rihel, J., Prober, D.A. (2017) Neuropeptide Y Regulates Sleep by Modulating Noradrenergic Signaling. Current biology : CB. 27(24):3796-3811.e5
- Singh, C., Oikonomou, G., Prober, D.A. (2015) Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish. eLIFE. 4:e07000
- Chen, S., Oikonomou, G., Chiu, C.N., Niles, B.J., Liu, J., Lee, D.A., Antoshechkin, I., and Prober, D.A. (2013) A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly. Nucleic acids research. 41(4):2769-2778
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