Genomic Feature
hu3568
- ID
- ZDB-ALT-130729-6
- Name
- hu3568
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Cuppen Lab
- Current Source
- Other Pages
Notes
Comment | Citation |
---|---|
hu3568 carries a threonine to alanine point mutation in myd88 creating a ... | van der Vaart et al., 2013 |
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 24: 20192465 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Leu>Stop (1)
- Flanking Sequence
-
TTTATTGACATGAAAATATCAAATTCTTTCCTTTTCTTTTCGGCTTAGTCCCTTAAAATAAAAAATAACAAGCATAATAAAAGTTTACTTTACCCAGAGAAGGATTAATTCTTTTTTTTCCTGTTGAACACAAAATAAGATACTTTAAAAAATGTTGAAAACCTGTAACCATTGACTTGCATAGTAATTGTTTGTCCTTCTATGGGTGTCAATGGTTGCAGAGTTTAAAAACATTCAGCAAAATATCTTCTTTTGTGTTCAATATGAAAAGGAAACTCATATAGATTTGGAACCACCTGAGGTTGAGTAATAGTGAGATAATTTTCATTTTTGGGTGAACTATCCCTTTAATAACAACGACAAAAAATAATATTTGATAATGCAACAATTAAATAATATATTGAAGCGAACAAAGAAAAGCAATAAACACATGGAATTTAGATGACGTACCTAAAATTTCTTTGAGCTCGGATATGACATCTTTCCTTTCAGCTTTTTCT
A/T AAATCGACAGTAAATTCGCTACTGTGGCGTCTGGACGAGTTTCCCAGTCCGTCAAGACCTTTTCAAAGGGACATTCTCTTTTCTCGAAGTTTTTGATCTCCAGGTACGTGAAGTCCATCAGTTCTGCCACTGTCCTCCAGTCTGCCGCCACAGTGTTTGTTGGGTTTAGGAACAGACCCAGTTTCTTTCGGAAACTGCAGTTTAAAGCTGTTACTGGAATCGCCTCATGGTCTATACTTAACTTTGATGCCATATTTATTAGCAAAACCTCTGTTATCCAGCGAAGTTGTTGTATATCTCCGCGTTACCCCGAAAAGAAACGTGAATTAAAAAAGTAAAATAGTTTAACGTTAATATATTTTAAGTTGTCATTTCCTGAAGTTACGGATATACTGAACTTTAAGAAAACAAATTTACGAACTGAAGTGCACCACGCAAGTTGGCAAGTTCACGTTACAACTACACAACAAGCAAAGCGAAGATTGAGGAAATGCTAGCTA - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
myd88hu3568/hu3568 | Homozygous | ♀+/- ♂+/- | 7 figures ![]() | 7 figures ![]() | |
myd88hu3568/hu3568 | Homozygous | ♀-/- ♂-/- | Fig. 3 from Troll et al., 2018 | ||
myd88hu3568/hu3568 (AB) | Homozygous | ♀-/- ♂-/- | 5 figures ![]() | 4 figures ![]() | |
myd88hu3568/hu3568 (AB) | Homozygous | ♀+/- ♂+/- | |||
myd88hu3568/hu3568 (AB/TL) | Homozygous | Unknown | Fig. 1 ![]() | ||
myd88hu3568/+ | Heterozygous | Unknown | Fig. 3 from Troll et al., 2018 | ||
myd88hu3568/hu3568; gl22Tg | Complex | Fig. 3 from Cunha et al., 2020 | |||
myd88hu3568/hu3568; gl22Tg; ue6Tg | Complex | 2 figures from Cunha et al., 2020 | |||
myd88hu3568/hu3568; i114Tg | Complex | Fig. 1 ![]() | |||
myd88hu3568/hu3568; i114Tg | Complex | Fig. 5 ![]() |
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Supplemental Information
- Genotyping protocol
- None
- Liu, L., Hu, W., Kerman, F.D., Spaink, H.P. (2025) Toll-like receptor adaptor protein TIRAP has specialized roles in signaling, metabolic control and leukocyte migration upon wounding in zebrafish larvae. International journal of biological sciences. 21:823841823-841
- Goumenaki, P., Günther, S., Kikhi, K., Looso, M., Marín-Juez, R., Stainier, D.Y.R. (2024) The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration. Nature cardiovascular research. 3:115811761158-1176
- Xie, J., Meijer, A.H. (2024) Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum. Frontiers in cellular and infection microbiology. 13:13318181331818
- Viana, F., Boucontet, L., Laghi, V., Schator, D., Ibranosyan, M., Jarraud, S., Colucci-Guyon, E., Buchrieser, C. (2023) Hiding in the yolk: A unique feature of Legionella pneumophila infection of zebrafish. PLoS pathogens. 19:e1011375e1011375
- Zhong, D., Jiang, H., Zhou, C., Ahmed, A., Li, H., Wei, X., Lian, Q., Tastemel, M., Xin, H., Ge, M., Zhang, C., Jing, L. (2023) The microbiota regulates hematopoietic stem and progenitor cell development by mediating inflammatory signals in the niche. Cell Reports. 42:112116112116
- Tyrkalska, S.D., Martínez-López, A., Pedoto, A., Candel, S., Cayuela, M.L., Mulero, V. (2022) The Spike protein of SARS-CoV-2 signals via Tlr2 in zebrafish. Developmental and comparative immunology. 140:104626
- Tyrkalska, S.D., Pedoto, A., Martínez-López, A., Ros-Lucas, J.A., Mesa-Del-Castillo, P., Candel, S., Mulero, V. (2022) Silica crystals activate toll-like receptors and inflammasomes to promote local and systemic immune responses in zebrafish. Developmental and comparative immunology. 138:104523
- Hosseini, R., Lamers, G.E.M., Bos, E., Hogendoorn, P.C.W., Koster, A.J., Meijer, A.H., Spaink, H.P., Schaaf, M.J.M. (2021) The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis. Virchows Archiv : an international journal of pathology. 479(2):265-275
- Hu, W., van Steijn, L., Li, C., Verbeek, F.J., Cao, L., Merks, R.M.H., Spaink, H.P. (2021) A Novel Function of TLR2 and MyD88 in the Regulation of Leukocyte Cell Migration Behavior During Wounding in Zebrafish Larvae. Frontiers in cell and developmental biology. 9:624571
- Cunha, M.I., Su, M., Cantuti-Castelvetri, L., Müller, S.A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T.J., Schmid, B., Lichtenthaler, S.F., Stadelmann, C., Simons, M. (2020) Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. The Journal of experimental medicine. 217(5):
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