Genomic Feature
hkz5
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 15: 23733531 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T in Exon 7 (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Gln>Stop at position 273 in RefSeq:NP_001002058.1 (1)
- Flanking Sequence
-
CACTGATTTATTTGAGGTTTTATCGCCCCACTGGTGCGACTATTACATCAATGATGGGTTTTTTTTCCAAAGCCTCAGATGTTATTTTCACAACCTGGAGAAAATTCTATAAAGAAATTCAGCTATGAAACTTGAAATTTCACCTCTGTGGCAGATAAAGTGAGATAACGTGAATGAGTGGGAGTGTGTTTCTTTGATGTGTGTGTGTATGTGCTGCGCTGCCAGGTGGAAATGCAGTGGGCTGAGGTTCATTGTGCTGCAGTTGGTGGGCAGTCAAAAAGGAGAAGTGATACTTTGGAAAATAGCCTAAAGGGGCTGAAAGCCTTTTCACGTGCTGCGCACATCTTCAAACACATCTCCCCTCCACTCACGTCCTGTTTTAATGTGGAAAACCCACTCTGTCTCTCTTGCTTCCTCCAACAGTGCTTCTGAAGTTTCGCACAGATAAAGGTCGCGATCCTCAACCTGACAGCTTTGCTGAAGACTCTCAACTGCTCTTG
C/T AAATCCGCGATGATGTCCTTGAGACTATGGGCTTAAGCTCGGATTTGCTCCCCAACACCTTTGTCAGGTACTCACTTAACCAGAAACTCAATGTTGCCATTCATTCTCTTCAGCATCTTCCTTTATTTCTAACTGAGGATGTGAGTGGTTTGCATGAATGACTTATTTTGACCAAAATAATTGGTCTGGTTTCAGATTCAGCTGGGCGTTTTTGAGTGCAACAGAATAGAACTGAATCTAGGTGCTTTTGTCCCATTTTAAGAACAGCTGTGTGAAAATGCCCACAGATTCTAGAGTGATGTTGAAAATATATGAGAGGCAGCATAGCGTTCAAATACACTGACGTTACATTCAAAAAAAAAAAATCGACATTTCATTTTACTTTCAAACTGCATTTTTTGTCCTTGATCTCCATGTGCACAGCCTTTGAAGTTGAAAGTTTAACAGTGTGATTCTGTTAAATTAACTGCAAAAGCTCTGGGACCTGCATTTTAAATGTC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| sae1hkz5/hkz5 | Homozygous | ♀+/- ♂+/- | 5 figures  from 2 publications | 4 figures from 2 publications | |
| sae1hkz5/+ | Heterozygous | Unknown | 2 figures from Yuan et al., 2015 | ||
| sae1hkz5/hkz5; la2Tg | Complex | 2 figures from Li et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Yuan, H., Zhang, T., Liu, X., Deng, M., Zhang, W., Wen, Z., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2015) Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Scientific Reports. 5:9011
- Li, X., Lan, Y., Xu, J., Zhang, W., and Wen, Z. (2012) SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish. Development (Cambridge, England). 139(23):4321-4329
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