Genomic Feature
y79
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 1: 12118426 (GRCz11) (1) Details
- Nucleotide change
- A/G
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>C in Exon 11 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Leu>Pro at position 475 (1)
- Flanking Sequence
-
GTGTGAGTTTAATATAAAAGTGCCACATTACAATCGATAACCATAAAGAACAAACTTTTGGTTGATTCGGACTACAGAGATCGTGACTCACTAGGCTGGCATCTGGAAGCGCAGGACGTCCTGGATTTTTGACAGCATGTATTTGTTCATCTCATGTGGCAGGTGTCCGATGGAGAGCAGCAGGTTCTTCACCTCCATGTAAGACGGATTACTGCTCATAATCACATCGGCTGCAGCCGCACGCACGTTCTTCTCGTAGATGCGCTGGTTTTGATGGTAGATGCGGTTCAAGGCTTTTTTCACCTGTGGACGGAGAGTGTTAATTGTTTTGAAGAATCGCTTTAGATGAGCTGATGTTGGATTTGTGATGTACCTCTGCTGTGATGAGCGCAGGGTCGTATCTCTGGAGCGCTGTGATGGCGATGGTGCTGTATGCTCCGACCTCAGATTCGGCATATTTGGCTAAAACAGGAATGCCTTCTGGCAGAAGAGCGTTTTTC
A/G GTGCTAACAGGTACATCTGAACCTCAGACTCCTCCTGAGTGCTGTCAGGCCCTGCTAACAGCAGCTCTTTCACCTTCAGCACAGCCTGTGCAAAGAAAATCCCATCAGAAACACAATCAATCAGCTTGAATTGATGAAAGTTATGGTAAATAATACTTTTTCTGATTTTGATTGTAATGCAATAATGTGCACATTTTGTAAAGCTGCTTTGAAACAGTTACTATTGTGAAAAGTGCTATACAAATAAACCTGACTTAAGTTGAATTTAATTGTGGCTGCATGGTGGCTCAGTGGTTAGCACTGTCTCATCACAGCAAGAAGGTCGCCGAGTCCTGACTGGGCCAGATGGCATTTCTGTGTATAGTTTGCATGTTTTCCCAGTGTTGGTGTAGGTTTCCTCCGGGTGCTCCGGTTTTCCCCATAGTCCAAAGACATGCGCTATAGGTGAATTGAATAATCTAAACTGGCTGTAGTGTATGAGTCTGTGTGAGAGTGTATGG - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
mttpy79/y79 | Homozygous | ♀+/- ♂+/- | 6 figures ![]() | Fig. 3 from Avraham-Davidi et al., 2012 | |
mttpc655/+; mttpy79/+ | Complex | 3 figures ![]() | |||
mttpy79/y79; y1Tg | Complex | 2 figures from 2 publications | |||
mttpy79/y79; y1Tg | Complex | 2 figures ![]() | Figure 4 ![]() | ||
mttpy79/y79; y7Tg | Complex | Fig. 1 from Avraham-Davidi et al., 2012 | Fig. 1 from Avraham-Davidi et al., 2012 | ||
mttpy79; apobb.1c832Tg | Complex | Fig 3 ![]() | |||
mttpy79/y79; apobb.1c832Tg/+ (AB) | Complex | Fig. 3 from Thierer et al., 2019 | 2 figures ![]() |
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Supplemental Information
- Genotyping protocol
- None
- Templehof, H., Moshe, N., Avraham-Davidi, I., Yaniv, K. (2021) Zebrafish mutants provide insights into Apolipoprotein B functions during embryonic development and pathological conditions. JCI insight. 6(13):
- Wilson, M.H., Rajan, S., Danoff, A., White, R.J., Hensley, M.R., Quinlivan, V.H., Recacha, R., Thierer, J.H., Tan, F.J., Busch-Nentwich, E.M., Ruddock, L., Hussain, M.M., Farber, S.A. (2020) A point mutation decouples the lipid transfer activities of microsomal triglyceride transfer protein. PLoS Genetics. 16:e1008941
- Thierer, J.H., Ekker, S.C., Farber, S.A. (2019) The LipoGlo reporter system for sensitive and specific monitoring of atherogenic lipoproteins. Nature communications. 10:3426
- Hen, G., Nicenboim, J., Mayseless, O., Asaf, L., Shin, M., Busolin, G., Hofi, R., Almog, G., Tiso, N., Lawson, N.D., Yaniv, K. (2015) Venous-derived angioblasts generate organ-specific vessels during embryonic development. Development (Cambridge, England). 142(24):4266-78
- Miyares, R.L., de Rezende, V.B., Farber, S.A. (2014) Zebrafish yolk lipid processing: a tractable tool for the study of vertebrate lipid transport and metabolism. Disease models & mechanisms. 7(7):915-27
- Ghajar, C.M., Peinado, H., Mori, H., Matei, I.R., Evason, K.J., Brazier, H., Almeida, D., Koller, A., Hajjar, K.A., Stainier, D.Y., Chen, E.I., Lyden, D., and Bissell, M.J. (2013) The perivascular niche regulates breast tumour dormancy. Nature cell biology. 15(7):807-817
- Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., and Yaniv, K. (2012) ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nature medicine. 18(6):967-973
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