Genomic Feature
jj203
- ID
- ZDB-ALT-120327-1
- Name
- jj203
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Malicki Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 23: 7716060 (GRCz11) (1) Details
- Nucleotide change
- C/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- C>T (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Polypeptide Truncation: Gln>Stop at position 369 (1)
- Flanking Sequence
-
GCTCAGTTGGTGCAACAAACATGAATGAACACAGTTCTCGCTCTCATGCCATCTTCGTCATCACCATTGAGTGCAGTGAGTTGGGTCCTGACGGAGAGAACCATATTCGAGTTGGGAAGCTTAACCTTGTTGACCTGGCAGGAAGTGAAAGACAGACCAAAACCGGTGCTCAAGGTGAACGCTTAAAAGAAGCCACTAAAATCAATCTCTCCTTGTCAGCTTTGGGAAACGTCATCTCAGCGTTGGTGGATGGAAGAAGCACCCATATCCCGTACCGTGACTCTAAGCTTACAAGACTTCTTCAAGACTCCTTGGGTGGAAACGCCCGAACGGTTATGGTGGCCAACATTGGACCAGCTTCCTACAATGTAGAGGAGACTCTAACGACGCTACGCTATGCAAACCGCGCCAAAAACATCAAGAACAAACCCCGTGTCAATGAAGACCCCAAGGATGCCCTTCTTCGGGAGTTTCAGGAGGAGATTGCCCGCTTGAAAGAA
C/T AGTTGGAGAAAAGGTCTGGAAGGAAGAGGAGGAGAAGGAGGAGAAGAAGGGTTGGAGAAGGAGGAGAGGAGTTTGAGGATGGGGAGGATGAAGAGGATGATGATGATGATGATGAAGACGAAGAGGAAGGAGTGGATGCAGATAAGAACATTGCAGATTATTGGCATGAGCAACAGGAGAAGCTGGAGAAGGAGAGGAGAGCCATCATGGAGGACCACAGTCTGGTGGCAGAGGAGAAACAGCGGCTGCTGAAGGAGAAGGAGAGGAAGATGACTGACCTGCACAAAGAGAAAGAGGCATCAGAGATGCTGACAGCCAAAGTTAAGGTTAGAAACTTCAAGCTTTGAATGAAATACAAATACATAATGGAGTCTGTAAGGTGTTAAGAAAAATTTCTGGATTTACAATAGGGATGTCCCAATTAGATTTTTTTTTAATTTTGAGAATCTATCGATACCGAAACCCAATCTGATACTTCTATAATACATAAAAAGAATAAA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| kif3bjj203/jj203 | Homozygous | ♀+/- ♂+/- | 7 figures  from 3 publications | 5 figures from 2 publications | |
| kif3bjj203/jj203; ouc2002Tg | Complex | 2 figures from Feng et al., 2017 | Fig. 4 from Feng et al., 2017 | ||
| kif3bjj203/jj203; ouc2036Tg/ouc2036Tg | Complex | Figure 4 from Sun et al., 2024 | Figure 4 from Sun et al., 2024 | ||
| kif3bjj203/jj203; kif3caouc2005/ouc2005 | Complex | Fig. 3 from Feng et al., 2017 | |||
| kif3bjj203/jj203 + MO1-kif3ca | Complex | Fig. 4 from Zhao et al., 2012 | |||
| kif3bjj203/jj203 + MO1-kif3cb | Complex | Fig. 4 from Zhao et al., 2012 | |||
| kif17sa0119/sa0119; kif3bjj203/jj203 | Complex | Fig. 4 from Zhao et al., 2012 | |||
| kif3bjj203/jj203; rhoouc2003/ouc2003 | Complex | Fig. 7 from Feng et al., 2017 | Fig. 7 from Feng et al., 2017 | ||
| kif3bjj203/jj203; rhoouc2003/+ | Complex | Fig. 7 from Feng et al., 2017 | |||
| kif3bjj203/jj203 + MO1-kif3ca + MO1-kif3cb | Complex | Fig. 4 from Zhao et al., 2012 |
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Supplemental Information
- Genotyping protocol
- None
- Sun, Y., Chen, Z., Jin, M., Xie, H., Zhao, C. (2024) Ciliary length regulation by intraflagellar transport in zebrafish. eLIFE. 13:
- Zhang, X., Jia, S., Chen, Z., Chong, Y.L., Xie, H., Feng, D., Wu, X., Song, D.Z., Roy, S., Zhao, C. (2018) Cilia-driven cerebrospinal fluid flow directs expression of urotensin neuropeptides to straighten the vertebrate body axis. Nature Genetics. 50(12):1666-1673
- Feng, D., Chen, Z., Yang, K., Miao, S., Xu, B., Kang, Y., Xie, H., Zhao, C. (2017) The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants. The Journal of biological chemistry. 292(42):17375-17386
- Zhao, C., Omori, Y., Brodowska, K., Kovach, P., and Malicki, J. (2012) Kinesin-2 family in vertebrate ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109(7):2388-2393
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