Genomic Feature
s436
- ID
- ZDB-ALT-091022-1
- Name
- s436
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 19: 29814011 (GRCz11) (1) Details
- Nucleotide change
- T/A
- Variant Notes
-
T to A point mutation at position 800; causes leucine to glutamine at aa 267
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A at position 800 (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Leu>Gln at position 267 (1)
- Flanking Sequence
-
TAACCGAAGGCCTTATAAATCTTTCTAGGTACCATCAAAGAGTGCTTTACATCGACATTGACATTCATCACGGTGATGGAGTTGAGGAAGCCTTTTACACAACAGACCGTGTCATGACTGTGTCTTTCCACAAGTATGGAGAGTATTTCCCGGGTACTGGAGACCTCAGAGTAAGTTCTGCAAGTTATGTGTGCATTTAGTTTGGTTATAGGAAAGGGTCCAAAACTCATTAATTAATAATATATTTTTTGCAGGATATTGGTGCAGGCAAGGGGAAGTATTACGCTGTAAATTACCCGCTCAGGGATGGTATTGATGATGAGTCCTATGAAGCCATATTCAAACCTGTAAGTCTGTAAACCGTACCAGATGTGACGATGTGTTTCTCTGAAATCAAGTCATGCAAATCTCCTTGTTTCTGATTGTCCTGTAGATCATGTCCAAAGTGATGGAGATGTACCAGCCCAGTGCTGTGGTGCTCCAGTGCGGCGCTGACTCTC
T/A GTCCGGAGATCGATTGGGCTGCTTTAACCTTACCATTAAAGGTATAAAAGTTTAATAAAACTTCAGAAAAGATTTCTAAGTTGGCTAGGCTTCATGTCTAAAAGCTTTGTGGGTTCTTCAGGTCATGCCAAGTGTGTAGAGTACATGAAGAGCTTTAACCTGCCGCTGCTCATGCTGGGAGGTGGAGGCTACACCATTAGAAACGTGGCCCGCTGCTGGACTTTCGAGACAGCTGTAGCACTGGACAGCACCATTCCTAATGGTCAGGAAATACTCTGCCTTGGAAGATTTTCTCTTGTGTTTTTTTATTTTTCAAGGCAAACTTCACTTAACTTGTTGATTTTTGTTTCATCAGAGCTCCCGTACAATGATTACTTTGAGTATTTTGGACCTGACTTCAAGCTCCACATCAGCCCCTCCAACATGACCAATCAGAACACAAATGACTACCTGGAAAAGATCAAGTAAGTGGGGTAAAGGACTAGAGGTGCTCCGTTTAT - Additional Sequence
- None
Fish
Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
---|---|---|---|---|---|
hdac1s436/s436 | Homozygous | ♀+/- ♂+/- | Fig. 7 ![]() | 9 figures ![]() | |
hdac1s436/s436 (AB/TL) | Homozygous | ♀+/- ♂+/- | |||
hdac1s436 | Unknown | ♀+/- ♂+/- | Fig. 3 ![]() | ||
hdac1s436/s436; gz4Tg | Complex | Fig. 3 ![]() | |||
hdac1s436/s436; gz15Tg | Complex | Fig. 3 ![]() | |||
hdac1s436/s436; rw0405bTg; rw0410hTg/rw0410hTg | Complex | Fig. S2 ![]() | Fig. S2 ![]() | ||
hdac1s436/s436; s854Tg | Complex | 3 figures ![]() | 5 figures ![]() | ||
hdac1s436/s436; rw0405bTg; rw0410hTg/rw0410hTg + MO2-ssrp1a | Complex | Fig. S2 ![]() | Fig. S2 ![]() |
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Supplemental Information
- Genotyping protocol
- None
- Román, A.C., Vicente-Page, J., Pérez-Escudero, A., Carvajal-González, J.M., Fernández-Salguero, P.M., de Polavieja, G.G. (2018) Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish. Genome biology. 19:55
- Jacob, J., Ribes, V., Moore, S., Constable, S.C., Sasai, N., Gerety, S.S., Martin, D.J., Sergeant, C.P., Wilkinson, D.G., and Briscoe, J. (2014) Valproic Acid silencing of ascl1b/ascl1 results in the failure of serotonergic differentiation in a zebrafish model of Fetal Valproate Syndrome. Disease models & mechanisms. 7(1):107-17
- Koltowska, K., Apitz, H., Stamataki, D., Hirst, E.M., Verkade, H., Salecker, I., and Ober, E.A. (2013) Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis. Development (Cambridge, England). 140(9):1912-8
- Ryan, S., Willer, J., Marjoram, L., Bagwell, J., Mankiewicz, J., Leshchiner, I., Goessling, W., Bagnat, M., and Katsanis, N. (2013) Rapid identification of kidney cyst mutations by whole exome sequencing in zebrafish. Development (Cambridge, England). 140(21):4445-4451
- Noël, E.S., Reis, M.D., Arain, Z., and Ober, E.A. (2010) Analysis of the Albumin/alpha-Fetoprotein/Afamin/Group specific component gene family in the context of zebrafish liver differentiation. Gene expression patterns : GEP. 10(6):237-243
- Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A. (2008) Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology. 322(2):237-250
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