Genomic Feature
tm213
- ID
- ZDB-ALT-020715-8
- Name
- tm213
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- Zebrafish International Resource Center (ZIRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 3: 43600982 (GRCz11) (1) Details
- Nucleotide change
- A/T
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- T>A (1)
- Transcript Consequence
- Missense (1)
- Protein Consequence
- Amino Acid Substitution: Leu>Gln at position 399 (1)
- Flanking Sequence
-
ATTCATTTGAGTAGGTAATTCAGCTCATAAGTTTTTAAAATAAAATCAGTTGTTTGCGGTATAAAAATACGAGATTTTGAAATATTTATTAGCTAATATATCGGTTATTGGCCTCCAAATCGTAAGAGTAAGCTGTTATCAATATCAGTAAAAAAAAAAAATAATAATAATAAAAATATATTGGTGCATCCCTACAGAGAAGTATAATTGCTCACACCAACATCAGCTACATGCAAGATATATGTTGTGGGGTATGGCATAAATTGCTTATCAATAAATGATGCTCCTTCATTCCAAACCAAAATTCCTAAATCTAAAAATAAACTAGTGACAACAAATTGTAACAGAATTTTAATTAATTACACCAGGAAATTCATCCAGTCTAATTATACCTCAAAATGCGTTAGCAGTGTGCTGATGGAGCTGTACTCACCAGTCGAACCCTCTTGAGACGCTCCTCCAGCTTCTCCTGCGCCTCTCGTTCCCTCAACACCCCCTCC
A/T GCCTGCTGATCAGCTCCGCCGCAAACTTCTCTGGCTCAACGTGAATATCCTTTGGTATCCGGTTTGTGCGCTGATGGGAAGACAATGAAAGAACTCAAGGTCACCATTCACATTTAATGCGATGCTGTGGAGAAAACACCTCCAGCTGTTGATTATACAGGTATGTGGACAGACAAAAATAACAGAGGAACATTAAAACGGGCTGGACAGACAAATGGAGGACACATTTTTGGACAATGTGTGATAGAGAATGAACACGAGGATTCTGTATACACATCGGTTTCAGTTTAAAAGCATCACCTCAAGGACAAAACATGGTACATCTCCAGCAAACAGGATAGACTGCTGAAATCCATGTTTACAGCTGCCAAATATATCATGTCAATCAACATACAGCAATTTCGTGAGGAACTAGCTTATTCTGTACACGCAAATGAATGATAATAGGGATTTGGAGATTCACTTAAATATTTAAATGTGGTTGTCATGGAATATTAGGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| axin1tm213/tm213 | Homozygous | ♀+/- ♂+/- | 16 figures  from 9 publications | 9 figures from 5 publications | |
| axin1tm213/tm213 | Homozygous | Unknown | Fig. for (tm213) from Phenotype Annotation (1994-2006) | 6 figures from 4 publications | |
| axin1tm213/tm213 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 7 from Schneider et al., 2012 | Fig. 7 from Schneider et al., 2012 | |
| axin1tm213/tm213 (TU) | Homozygous | ♀+/- ♂+/- | Fig. 2 from Li et al., 2012 | ||
| axin1tm213/+ | Heterozygous | Unknown | Fig. 3 from Meani et al., 2009 | ||
| axin1tm213/+ (AB) | Heterozygous | Unknown | |||
| axin1tm213/tm213; b1231Tg | Complex | Fig. 3 from Neal et al., 2013 | |||
| axin1tm213/tm213; p311Tg | Complex | Fig. 11 from Seiler et al., 2012 | |||
| axin1tm213/tm213; rw017Tg; zf15Tg | Complex | Fig. 5 from Carl et al., 2007 | |||
| axin1tm213/tm213 + MO2-myd88 | Complex | Fig. 4 from Cheesman et al., 2011 |
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Supplemental Information
- Genotyping protocol
- None
- Powell, G.T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R.M., Hawkins, T.A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D.W., Li, V.S.W., Wright, G.J., Jones, E.Y., Wilson, S.W. (2024) Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain. Science (New York, N.Y.). 384:573579573-579
- Guglielmi, L., Bühler, A., Moro, E., Argenton, F., Poggi, L., Carl, M. (2020) Temporal control of Wnt signaling is required for habenular neuron diversity and brain asymmetry. Development (Cambridge, England). 147(6):
- Brastrom, L.K., Scott, C.A., Dawson, D.V., Slusarski, D.C. (2019) A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Biomedicines. 7(2)
- Johansson, M., Giger, F.A., Fielding, T., Houart, C. (2019) Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools. Developmental Cell. 51(6):775-786.e3
- García-Lecea, M., Gasanov, E., Jedrychowska, J., Kondrychyn, I., Teh, C., You, M.S., Korzh, V. (2017) Development of Circumventricular Organs in the Mirror of Zebrafish Enhancer-Trap Transgenics. Frontiers in Neuroanatomy. 11:114
- Abrams, J., Einhorn, Z., Seiler, C., Zong, A.B., Sweeney, H.L., Pack, M. (2016) Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility, and vascular function in zebrafish. Disease models & mechanisms. 9(5):529-40
- Dyer, C., Blanc, E., Stanley, R.J., Knight, R.D. (2015) Dissecting the role of Wnt signaling and its interactions with FGF signaling during midbrain neurogenesis. Neurogenesis (Austin, Tex.). 2:e1057313
- Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
- Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27
- Huysseune, A., Soenens, M., Elderweirdt, F. (2014) Wnt signaling during tooth replacement in zebrafish (Danio rerio): pitfalls and perspectives. Frontiers in Physiology. 5:386
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