FIGURE

Figure 5

ID

ZDB-FIG-210915-33

Publication

Berlingerio et al., 2021 - Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis

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Figure 5

Increased apoptosis in PTECs with vacuoles in ctns^−/− zebrafish. (A,B) Representative images of the cleaved caspase-3 immunostaining of tubules of wild-type (A) and ctns^−/− (B) 18-month-old zebrafish. The scale bars represent 50 µm. (C,D) The bottom panels show a higher magnification of the boxed areas in the upper panels. Details of PTECs with cytoplasmic vacuoles (*). The scale bars represent 50 µm. (E,F) Representative images of the cleaved caspase-3 immunostaining of glomerulus of wild-type (E) and ctns^−/− (F) 18-month-old zebrafish. The scale bars represent 50 µm. (G) The quantification of the tubular caspase-3 staining positive area in wild-type and ctns^−/− zebrafish in both genders. Each dot represents one zebrafish, for a total of n = 3 wild-type and n = 3 ctns^−/− 18-month-old zebrafish. Two-way ANOVA with Fisher’s least significant difference (PLSD) test: ** p < 0.01; *** p < 0.001.

Expression Data

Antibody:	Ab5-casp3
Fish:	AB ctns^{sa14661/sa14661} (AB)
Anatomical Term:	proximal convoluted tubule
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ctns^{sa14661/sa14661} (AB)
Observed In:	proximal convoluted tubule proximal convoluted tubule apoptotic process proximal convoluted tubule vacuole
Stage:	Adult

Phenotype Detail

Acknowledgments

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