FIGURE

Figure 3

ID

ZDB-FIG-210915-31

Publication

Berlingerio et al., 2021 - Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis

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Figure 3

Kidney cystine crystals in wild-type and ctns^−/− zebrafish PTECs. (A,B) Representative toluidine blue-stained images of renal proximal tubules in wild-type (A) and ctns^−/− (B) 18-month-old zebrafish. The scale bars represent 50 µm. (C,D) Figure 3C,D show a higher magnification of Figure 3A,B. Details of renal proximal tubules with cytoplasmic vacuoles ((D); *), rectangular and polymorphous vacuolar spaces ((D); black arrowheads). (E,F) Representative TEM images of the renal proximal tubule of wild-type (E) and ctns^−/− 18-month-old zebrafish (F). (F) Partial loss of proximal tubule brush borders (PB) and accumulation of the rectangular and polymorphous vacuoles (*) were observed in the renal proximal tubule of ctns^−/− zebrafish. The high-magnification view of the rectangle in the bottom right corner shows the polymorphous vacuoles and a large vacuole with straight membrane border segments (a straight line). The scale bars represent 5 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ctns^{sa14661/sa14661} (AB)
Observed In:	proximal convoluted tubule brush border proximal convoluted tubule vacuole
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.