FIGURE

Fig. 6

ID

ZDB-FIG-091215-43

Publication

Reischauer et al., 2009 - Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis

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Fig. 6

erbB2 promotes EMT in the epidermis of pen/lgl2 mutant larvae.

DIC images of the morphology of wild-type (A), lgl2,erbB2^+/- (B) and lgl2,erbB2^-/- (C) larvae at 108hpf. Keratin (D–F), E-cadherin (G–I), BrdU (J–L) and mmp9 (M–O) staining in wild-type (D, G, J, M), lgl2,erbB2^+/- (E, H, K, N) and lgl2,erbB2^-/-(F, I, L, O) larvae at 108hpf. The DIC images of the morphology reveals that cellular clumps, a typical characteristic of pen/lgl2 mutant larvae are present in lgl2,erbB2^+/- (B) but are absent in lgl2,erbB2^-/-(C). The keratin, E-cadherin and mmp9 staining in lgl2,erbB2^-/- (F, I, O) appear similar to wild-type (D, G, M) indicating erbb2 promotes the EMT phenotype in pen/lgl2 mutant larvae. Note that, in lgl2,erbB2^-/- larvae (L) BrdU incorporation does not decrease to wild-type levels (J).

Expression Data

Gene:	cdh1
Fish:	erbb2^st61/+; llgl2^to6/to6 erbb2^st61/st61; llgl2^to6/to6
Anatomical Term:	epidermal cell plasma membrane
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	erbb2^st61/+; llgl2^to6/+ erbb2^st61/+; llgl2^to6/to6 erbb2^st61/st61; llgl2^to6/to6
Observed In:	epidermal cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

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