Gene
cdh1
- ID
- ZDB-GENE-010606-1
- Name
- cadherin 1, type 1, E-cadherin (epithelial)
- Symbol
- cdh1 Nomenclature History
- Previous Names
-
- E-cadherin (1)
- hab
- half baked
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including adherens junction maintenance; embryonic morphogenesis; and germ cell migration. Localizes to several cellular components, including adherens junction; catenin complex; and microvillus. Human ortholog(s) of this gene implicated in several diseases, including blepharocheilodontic syndrome 1; breast cancer (multiple); carcinoma (multiple); cervix uteri carcinoma in situ; and reproductive organ cancer (multiple). Is expressed in several structures, including axial mesoderm; blastoderm; germ ring; nervous system; and pronephros. Orthologous to human CDH1 (cadherin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 62 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu736 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 21 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Blepharocheilodontic syndrome 1 | 119580 | ||
| Breast cancer, lobular, somatic | 114480 | ||
| Diffuse gastric and lobular breast cancer syndrome with or without cleft lip and/or palate | 137215 | ||
| Endometrial carcinoma, somatic | 608089 | ||
| Ovarian cancer, somatic | 167000 | ||
| {Prostate cancer, susceptibility to} | 176807 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020894 | Cadherin conserved site |
| Domain | IPR000233 | Cadherin, Y-type LIR-motif |
| Domain | IPR002126 | Cadherin-like |
| Domain | IPR014868 | Cadherin prodomain |
| Family | IPR039808 | Cadherin |
| Homologous_superfamily | IPR015919 | Cadherin-like superfamily |
| Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cadherin | Cadherin conserved site | Cadherin-like | Cadherin-like superfamily | Cadherin prodomain | Cadherin, Y-type LIR-motif | Catenin binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90Z37
|
864 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pan-Cadherin | polyclonal | Rabbit |
|
Sigma-Aldrich
|
28 | ||
| AB1-cdh1 | polyclonal | Rabbit |
|
11 |
Plasmids