FIGURE

Fig 3

ID

ZDB-FIG-200316-22

Publication

Weuring et al., 2020 - NaV1.1 and NaV1.6 selective compounds reduce the behavior phenotype and epileptiform activity in a novel zebrafish model for Dravet Syndrome

Other Figures

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Fig 3

Pharmacologic validation of <italic>Scn1Lab</italic> knockouts by 60 minutes (light blue) or 18 hours (dark blue) exposure of anti-epileptic drugs A) 50μM Carbamazepine B) 100μM Phenytoin C) 100μM Sodium valproate D) 12.5μM Stiripentol E) 50μM Fenfluramine F) 50μM Clemizole.

Dashed lines indicate a novel experimental plate with a seperate experimental group. Error bars = S.D., (-/-) = Scn1Lab knockout, n = 12 per group * <0.05 **<0.005 ***<0.0005.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	scn1lab^zu1/zu1
Conditions:	chemical treatment by environment: carbamazepine chemical treatment by environment: clemizole chemical treatment by environment: fenfluramine chemical treatment by environment: phenytoin chemical treatment by environment: GABA modulator chemical treatment by environment: valproic acid
Observed In:	swimming
Stage:	Day 5

Phenotype Detail

Acknowledgments

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